Registration Dossier
Registration Dossier
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EC number: 202-940-9 | CAS number: 101-41-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, acceptable, well documented publication, no GLP study, similar to guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Methyl phenylacetate
- EC Number:
- 202-940-9
- EC Name:
- Methyl phenylacetate
- Cas Number:
- 101-41-7
- Molecular formula:
- C9H10O2
- IUPAC Name:
- methyl phenylacetate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Doses:
- 1250, 2500, 5000 mg/kg bw
- No. of animals per sex per dose:
- 4 animals per dose (sex not specified)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 400 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 150 - <= 4 700
- Mortality:
- 1250 mg/kg bw = 1 animal
2500 mg/kg bw = 2 animals
5000 mg/kg bw = 3 animals - Clinical signs:
- In one rabbit at 5 mg/kg bw lethargy was observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute dermal toxicity study with rats the LD50 was determined to be 2400 mg/kg bw.
- Executive summary:
The acute dermal toxicity of the test item was determined in this study which was conducted with 4 rabbits. They received a dermal application of 1250, 2500 and 5000 mg/kg bw. The animals were observed for mortality and/or systemic effects for 14 days. Mortality was observed from the lowest concentration level onwards. The calculated LD50 was determined to be 2400 mg/kg bw. Toxic effects were found in 1/4 animals in the highest dose level. Signs of lethargy were observed.
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