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Diss Factsheets
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EC number: 252-240-2 | CAS number: 34840-23-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute Oral toxicity study in male and female Wistar rats
Testing facility: Bayer Industry Services, Leverkusen
Study no. T2070311 performed on April 3, 2001.
The registrant has a Letter of Access.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Quality of whole database:
- The study was conducted in accordance with OECD no.423 "Acute oral Toxicity - Acute Toxic Class Method" and Annex IVB, Part B.1 tris (Acute toxicity oral - Acute Toxic Class Method) to Directive 67/548/EEC of the Council of the European Communities of June 27, 1967 in its current version as amended for the twenty-second time by Dir.96/54/EEC and followed, in principle, the Health Effects Test guidelines (OPPTS 870.1100).
Additional information
A group of six fasted Wistar rats (3 males and 3females) received a single oral gavage dose of the test substance formulated in demineralized water with the aid of Cremophor EL 2% (v/v) and administered at a dose level of 2000 mg/kg bw.
At 2000 mg/kg in males and females the motility was decreased and both sexes showed piloerection, bradypnea and narrowed palpebral fissures. Additionally to the signs described above, in females reactivity was decreased, lacrimation increased, feces decreased (constipation) and eyelids closed. In one male rat diarrhea was observed. The signs observed started 20 minutes after administration and lasted until 2 days of the study.
No treatment effects on the body weight were observed.
The gross pathology investigations performed at the end of the post-treatment observation period did not afford any treatment-related findings.
Justification for selection of acute toxicity – oral endpoint
One available study
Justification for classification or non-classification
LD 50 rat > 2500 mg/kg bw
Based on the study, the test substance is to be regarded as relatively non toxic and not to be classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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