Registration Dossier
Registration Dossier
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EC number: 203-987-8 | CAS number: 112-58-3
Endpoint summary
Administrative data
Description of key information
The acute toxicity to Daphnia was experimentally determined to be EC50(48h) = 0.194 mg/L. The respective chronic effect concentration based on the OECD 211 for reproduction was determined to be EC10(21d) = 0.0136 mg/L. For the toxicity towards algae, the 72h-ErC50 and 72h-ErC10 values were determined to be > 0.067 mg/l and 0.0385 mg/l, respectively. The acute toxicity towards fish was experimentally determined with an LC50(96h) of 2.02 mg/l. The chronic toxicity towards fish was predicted to be 30d-NOEC = 0.031 mg/l.
The available acute aquatic EC50 (Daphnia) and chronic aquatic EC10 (Daphnia) were used as basis for the aquatic classification.
Additional information
In addition to the experimental results, a QSAR model (Ecological Structure-Activity Relationship (ECOSAR) version 1.11) was used to predict the aquatic toxicity of dihexyl ether resulting in the following effect concentrations:
Acute Algae 96h-EC50 = 0.562 mg/l
Chronic Algae 96h-ChV = 0.272 mg/l (96h-NOEC = 0.192 mg/l)
Acute Daphnia 48h-LC50 = 0.242 mg/L
Chronic Daphnia 21d-ChV = 0.051 mg/l (21d-NOEC = 0.036 mg/l)
Acute Fish 96h-LC50 = 0.324 mg/l
Chronic Fish 30d-ChV = 0.044 mg/l (30d-NOEC = 0.031 mg/l)
The calculated values are based on the calculated logKow value. The calculated acute Daphnia LC50 reflects the experimentally determined EC50 value and also the calculated result for fish is in the same range as the Daphnia results. The calculated algae-NOEC is almost an factor of 10 higher than the experimentally determined ErC10 value. Due to the low solubility and volatility of dihexyl ether it is highly likely that the experimental value is considerably lower as the ECx calculations are based on the measured geo. mean values to account for the decrease of test substance concentration over the course of the test.
Nevertheless the calculated results for the acute toxicity towards fish, as well as the calculated results for chronic toxicity towards fish are considered reliable, as fish does not appear to be the most sensitive species.
The available acute aquatic EC50 (Daphnia) and chronic aquatic EC10 (Daphnia) were used as basis for the aquatic classification.
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