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EC number: 201-121-3 | CAS number: 78-50-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From Dec. 02, 2009 to Dec. 24, 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was conducted according to OECD Test Guideline 405, in compliance with GLP. The test substance characterization, provided by the sponsor, was not conducted according to the Good Laboratory Practices. However, it was approved under ISO 9001: 2008 .
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- The test substance characterization, provided by the sponsor, was not conducted according to the Good Laboratory Practices. However, it was approved under ISO 9001: 2008 .
Test material
- Reference substance name:
- Trioctylphosphine oxide
- EC Number:
- 201-121-3
- EC Name:
- Trioctylphosphine oxide
- Cas Number:
- 78-50-2
- Molecular formula:
- C24H51OP
- IUPAC Name:
- 1-(dioctylphosphoryl)octane
- Test material form:
- other: Solid
- Details on test material:
- - Name of test material (as cited in study report): CYANEX® 921 Extractant
- Physical state: white solid
- Analytical purity: 90%
- Lot/batch No.: WE7060753
-Certificate of analysis: CYANEX921 dated 01-Dec-2009
- Storage condition of test substance: at room temperature and humidity.
-Expiration date of the lot/batch: 6 months from date of receipt
- Date of receipt: 04 Dec, 2009
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Source: Covance Research Products Inc., Denver. PA
Housing: the animals were housed 1/cage in suspended cages. Paper bedding was placed beneath the cages and changed at least three times/week.
Body weight range before the test: 2.9-3.1 kg
Diet: fresh PMI Rabbit Chow (Diet #5321)
Water: ad libitum
Photoperiod: 12 h light/dark cycle
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The contralateral eye served as a control.
- Amount / concentration applied:
- 61.3 mg (equivalent to 0.1 mL)
- Observation period (in vivo):
- 1, 24, 48 and 72 h following administration of the test substance.
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- 0.1 mL of test substance was instilled into one eye of each animal. Contralateral eye served as a control. Using a Mini-Maglite flashlight equipped with a high intensity bulb, the treated and control eye of each rabbit was examined for irritation of the cornea, iris and conjunctiva at 1, 24, 48 and 72 h following administration of test substance. Sodium fluorescein dye procedures were used at the 24 h observation interval. The eye was examined with the aid of an ultraviolet light source. Ocular reactions were graded according to the numerical Draize technique.
Body weights were recorded pretest and at termination.
Observations for toxicity and pharmacological effects were recorded at each ocular observation period and mortality observations were performed daily. All animals were humanely sacrificed using CO2 following study termination
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #1
- Remarks:
- (mean score)
- Time point:
- other: Overall at 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- conjunctivae score
- Remarks:
- redenss
- Basis:
- animal #2
- Remarks:
- (mean score)
- Time point:
- other: Overall at 24, 48 and 72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #3
- Remarks:
- (mean score)
- Time point:
- other: Overall at 24, 48 and 72 h
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Remarks:
- (mean score)
- Time point:
- other: Overall at 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Remarks:
- (mean score)
- Time point:
- other: Overall at 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Remarks:
- (mean score)
- Time point:
- other: Overall at 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Remarks:
- (mean score)
- Time point:
- other: Overall at 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Remarks:
- (mean score)
- Time point:
- other: Overall at 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Remarks:
- (mean score)
- Time point:
- other: Overall at 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- There was no corneal opacity or iritis noted at any observation period. Conjunctival irritation. noted in 3/3 eyes. cleared in one eye by 24 h and in two eyes by 72 h.
- Other effects:
- No clinical signs of systemic toxicity were observed. Body weights were also normal.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test substance produced mild eye irritation (Hall DA, 2010).
- Executive summary:
A study was conducted to evaluate the eye irritation potential of the test substance in rabbits according to OECD Guideline 405, in compliance with GLP. Test substance (0.1 mL, which is equivalent to 61.3 mg) was instilled in one eye of three New Zealand White rabbits with the help of a syringe-type applicator. The contralateral eye served as control. The treated and control eyes of each rabbit were examined for irritation of the cornea, iris and conjunctiva at 1, 24, 48 and 72 h following instillation of the test substance. The eye was examined with the aid of an ultraviolet light source. Ocular reactions were graded according to the numerical Draize technique. Toxicity and pharmacological effects were recorded at each ocular observation period and mortality was checked daily. All animals were humanely sacrificed using C02following study termination. There was no corneal opacity or iritis noted at any observation period. Conjunctival irritation, seen all animals, cleared in one eye by 24 h and in the other two by 72 h. The control eyes appeared normal at all observation periods. No abnormal physical signs were recorded. Under the study conditions, the test substance was not irritating to eyes (Hall DA, 2010).
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