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EC number: 942-764-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP study. The experiment was performed according to the guideline equivalent or similar to the OECD 402 (Acute dermal toxicity).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-({2-[(2-aminoethyl)amino]ethyl}carbamoyl)benzoic acid; 2-{[2-({2-[(2-carboxyphenyl)formamido]ethyl}amino)ethyl]carbamoyl}benzoic acid; 3,6,9,18,21,24-hexaazatricyclo[24.4.0.0¹¹,¹⁶]triaconta-1(30),11,13,15,26,28-hexaene-2,10,17,25-tetrone
- EC Number:
- 942-764-6
- IUPAC Name:
- 2-({2-[(2-aminoethyl)amino]ethyl}carbamoyl)benzoic acid; 2-{[2-({2-[(2-carboxyphenyl)formamido]ethyl}amino)ethyl]carbamoyl}benzoic acid; 3,6,9,18,21,24-hexaazatricyclo[24.4.0.0¹¹,¹⁶]triaconta-1(30),11,13,15,26,28-hexaene-2,10,17,25-tetrone
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Type of material: powder.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albinos rabbits
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 6 albinos rabbits (3males and 3 females)
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: Test material was applied to premoistened skin.
- Duration of exposure:
- 24 hours
- Doses:
- 300/ 1000 / 3000 mg/g
- No. of animals per sex per dose:
- Two animals for each dose level (one male and one female)
- Control animals:
- not specified
- Details on study design:
- Test item was applied at each dose level on one abraded and one intact animal.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 other: mg/kg
- Based on:
- test mat.
- Mortality:
- No mortality
- Clinical signs:
- other: The rabbits did not exhibit any unusual behavioral reactions following dermal exposure. Local skin recation after 24-hour exposure period were characterized by barely perceptible pale to red erythema. No skin reaction were noted at 7 and 14 days.
- Gross pathology:
- Necropsy examination of all rabbits sacrified at the end of the 14-day observation period, did not reveal any gross pathologix alterations.
Any other information on results incl. tables
Mortality and body weight:
Dose* (mg/kg) | Animal N° and sex | Individual bodyweight (kg) at test day 0 | Individual bodyweight (kg) at test day 14 | Number dead/ Number tested | Percent dead |
300 | 1 -M** 2 -F |
2.86 2.64 |
2.70 2.98 |
0/2 | 0 |
1000 | 3-M** 4 -F |
2.90 2.44 |
2.80 2.56 |
0/2 | 0 |
3000 | 5-M** 6 -F |
2.98 3.18 |
2.96 3.14 |
0/2 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute LD50 of the test material was determined to be greater than 3000 mg/kg.
- Executive summary:
Three males and three females albinos rabbits were used to detemined the acute dermale toxicity of the test material.
Two animals for each dose level (one male and one female): 300 / 1000 and 3000 mg/kg.
Test item was applied at each dose level on one abraded and one intact animal.
The observation period is 14 days after 24 hours exposure duration.
The rabbits did not exhibit any unusual behavioral reactions following dermal exposure. Local skin recation after 24-hour exposure period were characterized by barely perceptible pale to red erythema. No skin reaction were noted at 7 and 14 days.
Necropsy examination of all rabbits sacrified at the end of the 14-day observation period, did not reveal any gross pathologix alterations.
No mortality occured during the observation time.
The acute LD50 of the test material was dezermined to be greater than 3000 mg/kg.
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