6,8-dimethylnon-7-enal

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

08 November to 13 December 2007

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Remarks:

The study was conducted according to an internationally recognised method, and under GLP. The substance is adequately identified, but details on composition are missing. Therefore validation applies with restrictions.

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient - Shake Flask Method)

Deviations:

yes

Remarks:

pH not recorded, but no ionisation anticipated

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Remarks:

effective 16 March 2007 (validity 18 months)

Type of method:

flask method

Partition coefficient type:

octanol-water

Specific details on test material used for the study:

Storage conditions of test material: Stored at room temperature protected from direct sun light.

Analytical method:

gas chromatography

Key result

Type:

log Pow

Partition coefficient:

3.87

Temp.:

20 °C

pH:

ca. 0 - ca. 14

Details on results:

Measured value:
40 mL of pre-saturated water and 4 mL of pre-saturated n-octanol were mixed with 0.4 mL of a 10 g/L stock solution. The tubes were continuously rotated for 15 min and then centrifuged for 10 min at 3500 tr/min and 20 °C.
The test was reproduced using half and twice, respectively, the above volume ratio.
Mean Log Pow and observed interval = 3.87 [3.78 - 3.99]
The validity criteria were fulfilled: The six Log Pow values fell within a range of ± 0.3 units.

Table 4.7/1: Partition coefficient – results

 

n-octanol:water		Ratio 1:10		Ratio 2:10		Ratio 1:20
Replicate tube		1	2	1	2	1	2
Mass balance (%)		100.9	99.7	99.0	96.2	98.8	100.5
Calculated Log Pow		3.95	3.99	3.91	3.78	3.82	3.80

Mean Log Pow and SD = 3.87 +/-0.09

The validity criteria were fulfilled: The six LogPow values fell within a range of ± 0.3 units.

The pH of the water phase was not measured.

Conclusions:

The substance has low potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow <4).

Executive summary:

The partition coefficient of the test substance was determined under GLP according to EU A.8 guideline, shake flask method.

 

Determinations were conducted in duplicate for three solvents ratio, concentrations were measured using a GC-FID validated method. Individual results fulfilled the validity criteria for reproducibility, and mass balance was satisfactory, so the average value is retained.

 

The log P_ow was determined to be 3.87 at 20 °C.

Description of key information

The data is relevant for classification in aquatic chronic toxicity hazard class, according to CLP criteria.

The substance has low potential for bioaccumulation (log Kow<4).

Key value for chemical safety assessment

Log Kow (Log Pow):

3.87

at the temperature of:

20 °C

Additional information

A reliable experimental study, conducted according to a recognized EC method and under GLP, is available.

Despite minor restrictions due to incomplete test item identification, it is considered as key study, and the result is retained as key data.