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EC number: 449-160-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-09-06 to 1999-12-17
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study. The study was conducted according to the appropriate OECD test guideline and in compliance with GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Control and 100 mg/l
- Sampling method: 10 ml samples were taken from the approximate centre of the test vessels at the start of the test and again after 48 and 96 hours.
- Sample storage conditions before analysis: Samples were analysed on the day of collection. - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The test substance was added directly to dilution water. A short period of magnetic stirring was applied to accelerate the dissolving of the substance. The resulting test medium was clear and colourless
- Controls: Dilution water - Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: Common carp
- Source: Zodiac, proefacc, 'De Haar Vissen', Wageningen, The Netherlands
- Length at study initiation (length definition, mean, range and SD): 2.4 cm (+/-0.13)
- Weight at study initiation (mean and range, SD): 0.36 g (+/-0.03)
- Method of breeding: F1 from a single parent pair
- Feeding during test: none
ACCLIMATION
- Acclimation period: at least 12 days from delivery
- Acclimation conditions (same as test or not): same as test
- Type and amount of food: Trouvit
- Feeding frequency: Daily
- Health during acclimation (any mortality observed): <5% mortality in the 7 days prior to the start of the test. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 250 mg/l as CaCO3
- Test temperature:
- 20.1 - 20.7ºC
- pH:
- 7.7 - 8.1
- Dissolved oxygen:
- 6.1 - 9.1 mg/l
- Nominal and measured concentrations:
- Nominal concentrations: 0 (Control) and 100 mg/l
Analysis of samples taken at the start of the test showed that the concentration based on component M2 was in agreement with nominal (93%). The concentrations of components M3 and M4 were 89 and 79% of nominal. After 48 hours the concentrations of components M2 and M3 had declined by 78 and 97% and component M4 could not be detected. At the end of the test the concentrations of components M2 and M3 were below 10% of their intitial concentrations and component M4 was not detectable. - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: glass, 8 litre with 5 litres of test medium
- Aeration: gently aerated on days 2 and 3
- Renewal rate of test solution: static
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.50 g/l
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: ISO medium
- Culture medium different from test medium: no
- Intervals of water quality measurement: Daily
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours light, 8 hours dark
- Light intensity: no data
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): mortality observed daily
TEST CONCENTRATIONS
- Spacing factor for test concentrations: limit test
- Justification for using less concentrations than requested by guideline: range finding test showing no effects at a concentration of 100 mg/l
- Range finding study
- Test concentrations: 100 mg/l
- Results used to determine the conditions for the definitive study: no effects - Reference substance (positive control):
- yes
- Remarks:
- pentachlorophenol
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Mortality of control: 0
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- 96-h LC50: 0.06-0.15 mg/l - Reported statistics and error estimates:
- Limit test and therefore no statistical analysis required
- Sublethal observations / clinical signs:
Testing in a semi-static or flow-through system was considered to have little relevance due to the observed high rate of hydrolytical degradation of the three components. Instead, the assessment of the toxic potential of exposure of fish to A-1160 (methanol stripped) was considered to be more realistic in a static system which includes exposure to degradation products. Exposure to 100 mg/l in the final limit test induced no effect on survival. The swimming capacity of one fish was affected at the end of the test period. No mortality was observed in the control group. The 96h-LC50for carp exposed to A-1160 (methanol stripped) was > 100 mg/l in a static system. Considering the high rate of hydrolytical degradation of the three major components of A-1160 (methanol stripped), exposure to possible degradation products did not induce additional effects on survival.
- Validity criteria fulfilled:
- yes
- Conclusions:
- A test medium prepared at a nominal concentration of 100 mg/l of ureudopropyltrialkoxysilane, mixed methoxy and ethoxy esters (CAS No. 119612-64-2) was not acutely toxic to Cyprinus carpio over 96 hours. The result is considered to be reliable. The test organisms were exposed primarily to the hydrolysis products of the substance.
- Executive summary:
In a fish acute toxicity study in which carp were exposed to A-1160 (methanol stripped), no mortality occured at the limit concentration of 100 mg/L. The result is considered to be reliable. The test organisms were exposed primarily to the hydrolysis products of the substance.
Reference
Description of key information
LC50 (96h) > 100 mg/l (limit test), mortality, Cyprinus carpio (OECD 203), RL1
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- mg/L
Additional information
In an acute fish toxicity test according OECD 203 and GLP (NOTOX, 2000e), the 96h LC50 for carp Cyprinus carpio exposed to
Ureidopropyltrialkoxysilane, mixed methoxy and ethoxy esters (116912-64-2) was >100 mg/l in a static system. Testing in a semi-static or flow-through system was considered to have little relevance due to the observed high rate of hydrolytical degradation of the three components. The data were predominantly generated on the parent compound, which was supposed to display the principal aquatic hazard and the assessment of the toxic potential of exposure of fish to Ureidopropyltrialkoxysilane, mixed methoxy and ethoxy esters was considered to be more realistic in a static system which includes exposure to degradation products. Therefore, the test organisms were exposed primarily to the hydrolysis products of the substance and exposure to the possible degradation products did not induce additional effects on survival. The result is considered to be reliable.
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