Pentapotassium ({[(hydroxyphosphinato)methyl](phosphonatomethyl)nitroryl}methyl)phosphonate

Dermal absorption

Administrative data

Endpoint:

dermal absorption in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Report date:

1983

Materials and methods

Principles of method if other than guideline:

Application of radiolabelled substance and observation of absorption and excretion in urine.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Nitrilotrimethylenetris(phosphonic acid)

EC Number:

229-146-5

EC Name:

Nitrilotrimethylenetris(phosphonic acid)

Cas Number:

6419-19-8

Molecular formula:

C3H12NO9P3

IUPAC Name:

[nitrilotris(methylene)]tris(phosphonic acid)

Radiolabelling:

yes

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Vehicle:

water

Duration of exposure:

24 h

Doses:

200 µl of a 1% aqueous solution was applied to 10 cm² area of shaved skin.

No. of animals per group:

2 male, 2 female

Results and discussion

Absorption in different matrices:

absorption: 0.603% (male); 0.94% (female)

Total recovery:

excretion: the majority of the absorbed radiolabelled ATMP was excreted in the urine within 24 hours of treatment.

Applicant's summary and conclusion

Conclusions:

A neutralised solution of ATMP was tested for dermal absorption. It was concluded that absorption was very low (<1%) and that most of the absorbed substance was excreted in the urine.