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EC number: 208-060-1 | CAS number: 506-93-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988-09-15 to 1988-09-16
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- photometric method
- Key result
- Type:
- log Pow
- Partition coefficient:
- < -1.7
- Temp.:
- 20 °C
- pH:
- ca. 7.4
- Details on results:
- The analytic procedure as outlined in section 3.4 was found to be linear between 120 µg/ml and 10 µg/ml and its detection limit was found to be 5 µg/ml (see RCC NOTOX study 0917/C608).
Concentrations of test substance in buffer and n-octanol samples were calculated using the absorbance coefficient at 480 nm in Milli-Q - Conclusions:
- In the study performed according to OECD107, adopted May 12, 1981 the partition coefficient (n-octanol/water) for Guanidine Nitrate was determined to be < 0.02 (log Pow: < -1.70) at 20 ± 1°C.
- Executive summary:
In the study performed according to OECD107, adopted May 12, 1981 the partition coefficient (n-octanol/water) for Guanidine Nitrate was determined to be <0.02 (log Pow: <-1.70) at 20 ± 1°C.
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1. September1988 - 15. September 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Justification for type of information:
- Supporting information for read-across, structural analogue approach.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- adopted May 12, 1981
- GLP compliance:
- yes
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- photometric method
- Key result
- Type:
- Pow
- Partition coefficient:
- < 0.02
- Temp.:
- 20 °C
- pH:
- 7.4
- Key result
- Type:
- log Pow
- Partition coefficient:
- < -1.7
- Temp.:
- 20 °C
- pH:
- 7.4
- Conclusions:
- In a test according to OECD 107, Guanidine hydrochloride showed a log Kow < -1.70 (20 °C, pH 7.4).
- Executive summary:
In a test according to OECD 107, Guanidine hydrochloride showed a log Kow < -1.70 (20 °C, pH 7.4).
Referenceopen allclose all
An overall partition coefficient of < 0.02 was calculated. Expressed as its logarithm (base 10), the mean partition coefficient is <-1.70; individual values fall within the range of ± 0.3 log units and therefore meet the quality criterion. Temperature of measurement was 20 ± 1°C.
From the preliminary test a partition coefficient of 0.07 was calculated (test substance concentrations of 5 microg/ml (detection limit) and 69 microg/ml were calculated for the n-octanol and buffer phase, respectively).
The analytical procedure as outlined in section 3.4 was found to be linear between 120 microg/ml and 10 microg/ml and its detection limit was found to be 5 microg/ml The test substance was determined to be stable for at least 4 hours in Milli-Q water (results not shown).
Concentrations of test substance in buffer and n-octanol samples were calculated using the absorbance coefficient at 480 nm in Milli-Q.
An overall partition coefficient of < 0.02 was calculated. Expressed as its logarithm (base 10), the mean partition coefficient is < -1.70; individual values fall within the range of ± 0.3 log units and therefore meet the quality criterion. Temperature of measurement was 20 ± 1°C. pH values of the water phases are shown in Table 1; pH of the buffer solution was 7.4. In conclusion, the partition coefficient (n-octanol/water) for Guanidine Hydrochloride was determined to be < 0.02 (log pow: < -1.70) at 20 ± 1°C.
Description of key information
The partition coefficient (n-octanol/water) of Guanidine Nitrate was determined to be <0.02 (log Pow: <-1.70) at 20 ± 1°C
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -1.7
- at the temperature of:
- 20 °C
Additional information
In the study performed by RCC NOTOX (1988) the partition coefficient (n-octanol/water) for Guanidine Nitrate was determined to be <0.02 (log Pow: <-1.70) at 20 ± 1°C. The study was performed according to OECD107, adopted May 12, 1981. To enable functionalities within Chesar v.1.2, the partition coefficient (here being out of range with a value of logKow of -1.7) was set to the minimum value of the range advised by the implemented EUSES program, i.e. to >-1.
Additional supporting data from the read-across substance guanidine chloride were included to demonstrate the similar physico-chemical profile of both substances, used to substantiate the justification for read-across, outlined in chapter 13 of technical dossier.
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