Registration Dossier
Registration Dossier
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EC number: 931-534-0 | CAS number: 68439-57-6
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: gene mutation
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Environmental and human safety of major surfactants. Volume 1. Anionic surfactants. Part 4. Alpha olefin sulfonates
- Author:
- Little, A.D.
- Year:
- 1 993
- Bibliographic source:
- National Technical Service (NTIS) report No. PB94-102423
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Host mediated assay with mice
- GLP compliance:
- not specified
- Type of assay:
- other: host-mediated assay
Test material
- Reference substance name:
- Sulfonic acids, C14-16 (even numbered)-alkane hydroxy and C14-16 (even numbered)-alkene, sodium salts
- EC Number:
- 931-534-0
- Cas Number:
- 68439-57-6
- Molecular formula:
- C(4+2n)H(9+4n)SO4Na C(4+2n)H(7+4n)SO4Na n = 5-6
- IUPAC Name:
- Sulfonic acids, C14-16 (even numbered)-alkane hydroxy and C14-16 (even numbered)-alkene, sodium salts
- Reference substance name:
- Sulfonic acids, C14-16 (even numbered)-alkane hydroxy and C14-16 (even numbered)-alkene, sodium salts
- IUPAC Name:
- Sulfonic acids, C14-16 (even numbered)-alkane hydroxy and C14-16 (even numbered)-alkene, sodium salts
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): AOS
- Analytical purity: four products, 21-38% active
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intramuscular
- Duration of treatment / exposure:
- no data
- Frequency of treatment:
- no data
- Post exposure period:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5000mg/kg bw
Basis:
no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Examinations
- Tissues and cell types examined:
- Injected bacteria or yeast cells were recovered and investigated.
Results and discussion
Test results
- Sex:
- not specified
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
Any other information on results incl. tables
The test substance was not mutagenic in bacteria and yeast when metabolized by mice.
However, propane sultone at 460 mg/kg, which was tested in parallel, was mutagenic in both systems, while 1,4-butane sultone was found to be mutagenic for S. typhimurium but not mutagenic for S. cerevisiae. Both sultones were reported to be mutagenic in bacteria in vitro (Ames assay), as well.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
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