Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 239-707-6 | CAS number: 15630-89-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was carried out in accordance with the Health Effects Test Guidelines, U.S. Environmental Protection Agency Office of Pesticides and Toxic Substances (August 1982) and was performed in compliance with the conditions of GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Guideline:
- other: EPA Guideline
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Disodium carbonate, compound with hydrogen peroxide (2:3)
- EC Number:
- 239-707-6
- EC Name:
- Disodium carbonate, compound with hydrogen peroxide (2:3)
- Cas Number:
- 15630-89-4
- Molecular formula:
- CH2O3.3/2H2O2.2Na
- IUPAC Name:
- tetrasodium hydrogen peroxide dicarbonate
- Details on test material:
- moistened with saline
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Young adult female and male rabbits, Hra:(NZW)SPF, were procured, maintained individually in screen-bottom cages in temperature and humidity-controlled quarters, provided access to water ad libitum and a measured amount of High Fiber Rabbits Chow 5326, Purina Mills, Inc., and held for an acclimation period of at least 7 days. Five male and five female rabbits acclimated rabbits, weighing from 2510 to 2894 g, were chosen at random, treated, and maintained during the observation period as specified for the acclimation period.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- physiological saline
- Details on dermal exposure:
- TEST SITE
- Area of exposure: An area making up approximately 20 % of the total body surface area was shaved with an electronic clipper 24 hours before the test.
- % coverage: The area of application was covered with a 10 x 10 cm gauze patch secured with paper tape.
- Type of wrap if used: Saran wrap and Elastoplast tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): lukewarm water
- Time after start of exposure: 24 hours after exposure
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 g/kg bodyweight based upon each animal's bodyweight at study initiation - Duration of exposure:
- 24h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 animals
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were observed for clinical signs and mortality at 1, 2.5 and 4 hours after administration. Thirty minutes after removal of the test material the initial dermal irritation reading was made. Subsequent readings of dermal irritation were done on days 3, 7, 10 and 14. The animals were observed daily for clinical signs and twice per day for mortality. The animals were weighed prior to test material application, at day 7 and at termination of the experiment.
- Necropsy of survivors performed: yes - Statistics:
- No statistical method was performed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: No clinical signs related to the test material were observed.
- Gross pathology:
- Severe dermal irritation consisting of slight to severe erythema and edema, and slight to marked atonai, desquamation, coriaceousness, and fissuring. Other dermal effects included subcutaneous hemorrhaging, blanching, possible necrotic areas, eschar, exfoliation, and possible scar tissue.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance was not acutely toxic via the dermal route and the LD50 value was greater than 2000 mg/kg bodyweight.
- Executive summary:
The acute dermal toxicity of sodium percarbonate was evaluated in male and female rabbits according to the relevant guideline of the US EPA Office of Pesticides and Toxic Substances (August 1982) and following the conditions of GLP. Dermal toxicity was tested at a level of 2.0 g/kg bodyweight with physiological saline as the vehicle.
There was no mortality and no clinical signs related to the test material were observed after 14 days following treatment. Bodyweight losses of 10 to 128 g were noted for four animals at day 7 and in one animal at day 14. Dermal irritation was severe and consisted of slight to severe erythema and edema, and slight to marked atonai, desquamation, coriaceousness, and fissuring. Other dermal effects included subcutaneous hemorrhaging, blanching, possible necrotic areas, eschar, exfoliation, and possible scar tissue.
In conclusion, the LD50 value for acute dermal toxicity was found to be greater than 2000 mg/kg bodyweight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.