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EC number: 274-490-1 | CAS number: 70236-60-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- October from 2nd to 17th, 1979
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Test procedures cannot be subsumed under a testing guideline, nevertheless are well documented and scientifically acceptable. The test substance purity is unknown.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- Five male and five female rats were placed in a 435 litre stainless steel chamber with continuous air flow. The test material was introduced into a distilling flask at a constant rate by use of a Harvard pump. The vapours generated were introduced into the air stream. The dosage amount was calculated from the air flow and the amount of liquid material used. The animals were observed hourly during dosing and as late in the day as possible and then once daily for days 1-14. Mortality, toxicity and pharmacological effects were recorded. At 14 days the survivors were sacrificed. All animals were examined for gross pathology.
- GLP compliance:
- no
- Remarks:
- pre GLP
- Limit test:
- no
Test material
- Reference substance name:
- Disodium [2,4-dihydro-4-[(2-hydroxy-5-nitrophenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-)][3-hydroxy-4-[(2-hydroxy-1-naphthyl)azo]-7-nitronaphthalene-1-sulphonato(3-)]chromate(2-)
- EC Number:
- 274-490-1
- EC Name:
- Disodium [2,4-dihydro-4-[(2-hydroxy-5-nitrophenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-)][3-hydroxy-4-[(2-hydroxy-1-naphthyl)azo]-7-nitronaphthalene-1-sulphonato(3-)]chromate(2-)
- Cas Number:
- 70236-60-1
- Molecular formula:
- C36H21CrN8O11S.2Na
- IUPAC Name:
- disodium [2,4-dihydro-4-[(2-hydroxy-5-nitrophenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-)][3-hydroxy-4-[(2-hydroxy-1-naphthyl)azo]-7-nitronaphthalene-1-sulphonato(3-)]chromate(2-)-
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: supplier Ace Animals.
- Age at study initiation: at least 8 weeks old when received.
- Weight at study initiation: 225-274 g.
- Housing: housed 5/cage in suspended wire mesh cages (20" x 10" x 7"), except during dosing when they were individually housed.
- Diet: ad libitum, Fresh Purina rat chow.
- Water: ad libitum.
- Acclimation period: rats were equilibrated for at least one week in the test laboratory.
Apparently healthy rats were selected for the test.
ENVIRONMENTAL CONDITIONS
- Temperature: maintained at 20 - 21 °C.
The animal room, reserved exclusively for rabbits on acute tests, was kept clean in accordance with the standards of AAALAC of which the test laboratory is an approved member.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Total Volume of Air: 2175 litres/minute.
- Material Used: 6 ml.
- Exposure chamber volume: rats were placed in a 435 litre stainless steel chamber with continuous air flow.
- Test material administration: the test material was introduced into a distilling flask at a constant rate by use of a Harvard pump. Vapours generated were introduced into the air stream.
- Amount: the dosage amount was calculated from the air flow and the amount of liquid material used. - Duration of exposure:
- ca. 4 h
- Concentrations:
- Nominal Concentration: .013 mg/l.
- No. of animals per sex per dose:
- Five male and five female rats.
- Details on study design:
- - Duration of observation period following administration: the animals were observed hourly during dosing and as late in the day as possible and then once daily for Days 1-14.
- Frequency of observations and weighing: body weights were recorded pretest (Day 0) and on Days 7 & 14.
- Observation: mortality, toxicity and pharmacological effects were recorded.
- Necropsy of survivors performed: at 14 days the survivors were sacrificed.
- Other examinations performed: all animals were examined for gross pathology.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.013 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- 0/5 males-0/5 females
- Clinical signs:
- other: Animal #1 exhibited chromorhinorrhea on Day 1. Animal #2 exhibited chromorhinorrhea on Days 1, 2, 9 thru 12. Animal #3 exhibited chromorhinorrhea on Day 1. Animal #4 exhibited chromodacryorrhea on Day 2, 12 & 13 and ptosis on Day 14. At all other observa
- Body weight:
- Normal body weight changes were noted.
- Gross pathology:
- All animals were normal.
Any other information on results incl. tables
BODY WEIGHTS - g
An. # & Sex |
Day 0 | Day 7 | Day 14 |
1-M | 274 | 313 | 359 |
2-M | 250 | 287 | 327 |
3-M | 269 | 312 | 357 |
4-M | 268 | 324 | 376 |
5-M | 258 | 305 | 341 |
6-F | 227 | 237 | 252 |
7-F | 227 | 235 | 248 |
8-F | 226 | 244 | 265 |
9-F | 228 | 229 | 241 |
10-F | 225 | 228 | 246 |
Applicant's summary and conclusion
- Interpretation of results:
- other: not assessable under the CLP Regulation (EC 1272/2008) criteria
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The test material is not toxic at a nominal concentration of .013 mg/litres.
- Executive summary:
Method
Five male and five female rats were placed in a 435 litre stainless steel chamber with continuous air flow. The test material was introduced into a distilling flask at a constant rate by use of a Harvard pump. The vapours generated were introduced into the air stream. The dosage amount was calculated from the air flow and the amount of liquid material used. The animals were observed hourly during dosing and as late in the day as possible and then once daily for days 1-14. Mortality, toxicity and pharmacological effects were recorded. At 14 days the survivors were sacrificed. All animals were examined for gross pathology.
Result
All animals survived this test in generally good health. Normal body weight changes were noted. All animals were normal at necropsy.
The test material is not toxic at a nominal concentration of 0.013 mg/litres.
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