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Diss Factsheets
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EC number: 200-193-3 | CAS number: 54-11-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Density
Administrative data
Link to relevant study record(s)
- Endpoint:
- relative density
- Remarks:
- Other density types indicated (migrated information): density
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014-09-22 to 2014-09-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed in accordance with standard test protocols (OECD 109 resp. EU A.3) in a quality controlled laboratory. The study is valid according to criteria mentioned in the test protocols.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.3 (Relative Density)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- pycnometer method
- Type:
- density
- Density:
- 1.01 g/cm³
- Temp.:
- 20 °C
- Type:
- relative density
- Density:
- 1.01
- Temp.:
- 20 °C
- Conclusions:
- The density of nicotine corresponds to 1.0099 ± 0.0002 g/cm³ at 20.0 ± 0.4 °C. This value is the mean of two independent determinations ± the standard deviation. The standard deviation shows good correlation of the two determinations.
Therefore, the study is considered valid. - Executive summary:
The density of nicotine has been determined by the pycnometer method and corresponds to
1.0099 ± 0.0002 g/cm3at 20.0 ± 0.4 °C.
Reference
Results of the single determinations with the respective error:
Determination |
Density [g/cm3] |
Error of Determination [g/cm3] |
1 |
1.0097 |
0.0001 |
2 |
1.0100 |
0.0001 |
The density of the test item nicotine was calculated from
ρ = [(m3– m1) / (m2– m1)] · ρH2O
with
ρ |
density of test item to be calculated [g/cm3] |
m1 |
mass of empty pycnometer [g] |
m2 |
mass of pycnometer filled with water [g] |
m3 |
mass of pycnometer filled with test item [g] |
ρH2O |
density of water at test temperature (0.9982 g/cm3at 20.2°C) |
The error of each determination method was calculated from Δρ= (2·Δm·100%) / (m3– m1) + (2·Δm·100%) / (m2– m1) with
Δρ |
relative error of measured density |
Δm |
absolute error of single weighing |
m1 |
mass of empty pycnometer [g] |
m2 |
mass of pycnometer filled with water [g] |
m3 |
mass of pycnometer filled with test item [g] |
Mean values and standard deviations of the determined parameters:
Parameter |
Value |
Unit |
Standard Deviation |
Relative Standard Deviation |
volume of pycnometer |
10.81 |
cm3 |
0.0028 |
0.03 % |
density of test item nicotine |
1.0099 |
g/cm3 |
0.0002 |
0.02 % |
density of test item nicotine |
1009.9 |
kg/m3 |
0.2 |
0.02 % |
relative density of test item nicotine |
1.0099 |
|
0.0002 |
0.02 % |
Description of key information
Study was conducted in a quality controlled laboratory. The results are reliable without restriction. Key study is appropriate for the risk assessment.
Key value for chemical safety assessment
- Relative density at 20C:
- 1.01
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.