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EC number: 201-081-7 | CAS number: 78-08-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 Feb - 17 Feb 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Circular on Test Methods of New Chemical Substances (Japan), Alga growth inhibition test
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- according to the Japanese GLP Standard
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
PHYSICO-CHEMICAL PROPERTIES
- Melting point: < 0°C
- Boiling point: 123°C
- Vapour pressure: < 2.7 kPa at 25 °C
- Water solubility (under test conditions): low
- Stability in water: Test item is hydrolyzed (half-life: within 30 min) - Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method: sampled directly by each vessel and pre-treatment was not performed
- Sample storage conditions before analysis: no strage before analysis
- Methanol was measured, since the test item was quickly hydrolyzed - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: test item was measured and diluted in dilution water by stirring for 120 min - Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- TEST ORGANISM
- Common name: Alga
- Strain: ATCC22662
- Source (laboratory, culture collection): American Type Culture Collection
- Age of inoculum (at test initiation): after 4-day preculture
- Method of cultivation: on a shaker
ACCLIMATION
- Acclimation period: 4 days (2006-02-10 ~ 2006-02-14)
- Culturing media and conditions (same as test or not): same as test - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
- Test temperature:
- 23.0 - 23.1 °C (23 ± 2 °C), measured at the study initiation, 24, 48 and 72 hours after exposure
- pH:
- 8.0 - 9.9, measured at the initiation and at the end of the study.
- Nominal and measured concentrations:
- Nominal concentration: 100 mg/L
Measured concentration: 89 mg/L (time-weighted mean; the concentration was determined based on the measured concentration of the hydrolysis product, methanol) - Details on test conditions:
- TEST SYSTEM
- Test vessel: 500 mL Elenmyer-flask
- Type (delete if not applicable): closed
- Material, headspace, fill volume: glass, 490 mL, 100 mL
- Initial cells density: 5000 cells/mL
- Control end cells density: 855900 ± 20700 cells/mL
- No. of vessels per concentration (replicates): 6
- No. of vessels per control (replicates): 6
GROWTH MEDIUM
- Standard medium used: yes
TEST MEDIUM / WATER PARAMETERS
- Culture medium different from test medium: same medium
OTHER TEST CONDITIONS
- Sterile test conditions: yes
- Adjustment of pH: no adjustment
- Photoperiod: continuously
- Light intensity and quality: 65 µE/m2/s
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Determination of cell concentrations: counting chamber; electronic particle counter;
TEST CONCENTRATIONS
- Range finding study: performed twice.
- Test concentrations: 1) 1, 10 and 100 mg/L, 2) 100 mg/L
- Results used to determine the conditions for the definitive study:
1) Inhibition rate was 16% (close system), -42% (open system) in 1 mg/L, 12% (close system), -44% (open system) in 10 mg/L, and 1% (close system), -36% (open system) in 100 mg/L, respectively.
2) Inhibition rate was -14% (close system) and 6% (open system). Measured concentration was 108 mg/L at the study initiation and 87 mg/L in a close system at the end of the study. - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate (analytical grade)
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 89 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: the concentration was determined based on the measured concentration of the hydrolysis product, methanol
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 89 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: the concentration was determined based on the measured concentration of the hydrolysis product, methanol
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 89 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: the concentration was determined based on the measured concentration of the hydrolysis product, methanol
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 89 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: the concentration was determined based on the measured concentration of the hydrolysis product, methanol
- Details on results:
- - Exponential growth in the control (for algal test): yes
- Observation of abnormalities (for algal test): no abnormality was observed - Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- EC50: 0.428 ± 0.0683 mg/L - Reported statistics and error estimates:
- Student's t-test, subsequent to F test for homogeneity of variances.
- Conclusions:
- The NOEC of 2768-02-7 to algae was reported to be >89 mg/l for both biomass and growth rate. Due to the rapid rate of hydrolysis, the concentration was determined based on the measured concentration of the hydrolysis product, methanol.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions (No GLP or analysis), study period of 7d but not appropriate for current regulatory purposes days
- Qualifier:
- according to guideline
- Guideline:
- other: US EPA 67014-73-0
- Deviations:
- yes
- Remarks:
- :7 day exposure period
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- no data
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- no data
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 7 d
- Hardness:
- no data
- Test temperature:
- no data
- pH:
- no data
- Dissolved oxygen:
- no data
- Salinity:
- not applicable
- Nominal and measured concentrations:
- Nominal concentrations: 0(Control), 25, 100 and 1000 mg/l
- Details on test conditions:
- TEST SYSTEM
- Test vessel:Flask
- Material: Polycarbonate
- Aeration: no data
- Renewal rate of test solution: static test
- Initial cells density: 50000 cells/ml
- Control end cells density: approx. 2000000 cells/ml
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 3
GROWTH MEDIUM
- Standard medium used: sterilised algal broth
- Detailed composition if non-standard medium was used: no data
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: sterilized algal broth
- Culture medium different from test medium: no data
- Intervals of water quality measurement: no data
OTHER TEST CONDITIONS
- Sterile test conditions: yes
- Adjustment of pH: no data
- Photoperiod: no data
- Light intensity and quality: no data
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): Growth rate and cell number
- Determination of cell concentrations: counting chamber
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 4.0-10
- Range finding study: no data - Reference substance (positive control):
- no
- Duration:
- 7 d
- Dose descriptor:
- EC50
- Effect conc.:
- 210 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: final yield
- Remarks on result:
- other: 163-276
- Duration:
- 7 d
- Dose descriptor:
- EC10
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: final yield
- Remarks on result:
- other: 21-46
- Duration:
- 7 d
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 25 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: final yield
- Details on results:
- - Exponential growth in the control (for algal test): yes
- Any stimulation of growth found in any treatment: no - Reported statistics and error estimates:
- The ECx values were calculated using methods described in the Handbook of Phycological Methods (1973) in conjunction with probit analysis based on Finney's Method (Statistical Methods in Biological Assay, 1952).
- Validity criteria fulfilled:
- yes
- Conclusions:
- Measured data was not available for triethoxy(vinyl)silane (CAS 78-08-0), therefore data was read across from the comparable substance, trimethoxyvinylsilane (CAS 2768-02-7) A 7-day EC50 value of 210 mg/l and NOEC of 25 mg/l have been reported fot the effects of the test substance on final yield of Pseudokirchnerella subcapitata. It is likely that the test organisms were primarily exposed to the hydrolysis products of the substance.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to overall summary (IUCLID Section 6.1) and attached justification for grouping in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 89 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: the concentration was determined based on the measured concentration of the hydrolysis product, methanol
- Remarks:
- MOE 2006
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 89 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: the concentration was determined based on the measured concentration of the hydrolysis product, methanol
- Remarks:
- MOE 2006
- Duration:
- 7 d
- Dose descriptor:
- EC50
- Effect conc.:
- 210 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: final yield
- Remarks on result:
- other: 163-276
- Remarks:
- Dow Corning 1979
- Duration:
- 7 d
- Dose descriptor:
- EC10
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: final yield
- Remarks on result:
- other: 21-46
- Remarks:
- Dow Corning 1979
- Duration:
- 7 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 25 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: final yield
- Remarks on result:
- other:
- Remarks:
- Dow Corning 1979
Referenceopen allclose all
Table 1. Calculated concentration of the test substance using methanol concentration
Nominal concentration (mg/L) |
Mean measured concentration, mg/L (Percent of nominal) |
Mean measured concentration (*), mg/L |
|
|||
0 hour |
24 hours |
48ours |
72ours |
|
||
Control |
< 0.03 |
< 0.03 |
< 0.03 |
< 0.03 |
|
|
100 |
105 (105 |
100 (100 |
75.3 (75) |
80.2 (80) |
89 (89) |
*: Time-weighted mean measured concentration
Table 2. Growth inhibition (%)
Nominal conc. (mg/L) [Mean measured conc. *] |
Inhibition rate (%) Growth rate |
Inhibition rate (%) Biomass |
Control |
- |
- |
100 [89] |
0.3 |
0.5 |
*: Time-weighted mean measured concentration
The test substance had a negligible effect on exponential growth of the algae.
Description of key information
Key study: A 72-hr NOEC of >= 89 mg/l (growth rate and biomass Pseudokirchneriella subcapitata, Circular on Test Methods of New Chemical Substances (Japan)
Supporting study: A 7-day EC50 of 210 mg/l and NOEC of 25 mg/l h (yield of Pseudokirchneriella subcapitata, US EPA 67014-730), RL2
Key value for chemical safety assessment
Additional information
Measured data were not available for triethoxy(vinyl)silane (CAS 78-08-0), therefore data were read across from the analogue substance, trimethoxyvinylsilane (CAS 2768-02-7).
According to Circular on Test Methods of New Chemical Substances (Japan) a 72h NOEC of 89 mg/l was derived concerning the effects of the test substance on growth rate and biomass of Pseudokirchneriella subcapitata (Ministery of the Environment, Government of Japan, 2006c). In the supporting study, a 7-day EC50 value of 210 mg/l and a NOEC of 25 mg/l for the effects of the test substance on final yield of Pseudokirchneriella subcapitata were derived (Dow Corning Corporation, 1979).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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