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Diss Factsheets
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EC number: 451-900-9 | CAS number: 894406-76-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to international guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1994
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- other: FIFRA (40 CFR)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- other: solid gel
- Details on test material:
- - Name of test material: Didecyldimethylammonium carbonate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: Young adults
- Weight at study initiation:
Male: 242 – 300 g
Female: 189 – 254 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 5 % - Doses:
- Dose range finding: 100, 250, 500 mg a.i./kg
Definitive test: 25, 50, 100, 200, 400, 800 mg a.i./kg - No. of animals per sex per dose:
- Dose range finding: 2/sex/group
Definitive test: 5/sex/group - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Day 0, 7 and 14
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs
In addition the post-exposure observation period was extended to 21 days for those rats exposed to 200 and 400 mg/kg of Carboquat due to the toxic effects observed on day 14.
Results and discussion
- Preliminary study:
- For results see table 1a below. Definitive test doses were based on the results obtained in the preliminary test.
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 245 mg/kg bw
- Based on:
- act. ingr.
- 95% CL:
- 135 - 443
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 25 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- For results see table 1b below.
- Clinical signs:
- other: A variety of clinical signs were observed for males and females in the 800 mg a.i./kg bw treatment group which died as a result of treatment. These signs were generally indicative of increased secretions, changes in the appearance of the fur and posture,
- Gross pathology:
- Findings in the animals that died during the observation period were those generally seen in agonal animals with additional observation generally seen in response to the oral administration of an irritating material. All animals at the 400 mg a.i./kg bw dose level and one animal at the 200 mg a.i./kg bw dose level which survived the observation period exhibited tissue adhesions in the peritoneal cavity in the area of the stomach. Furthermore, all animals which survived the observation period at the 100 mg a.i./kg bw dose level exhibited livers and spleens which appeared pitted. In all other animals which survived the observation period there were no gross pathological findings.
Any other information on results incl. tables
Table 1a: Group incidence of mortality - Dose range finding screen:
Dose |
Mortality |
|
Male |
Female |
|
500 |
2/2 |
2/2 |
250 |
2/2 |
2/2 |
100 |
0/2 |
0/2 |
Table 1b: Group incidence of mortality - Definitive test
Dose |
Mortality |
|
Male |
Female |
|
800 |
5/5 |
5/5 |
400 |
2/5 |
4/5 |
200 |
2/5 |
3/5 |
100 |
1/5 |
0/5 |
50 |
0/5 |
1/5 |
25 |
0/5 |
0/5 |
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral toxicity study revealed a LD50 of 245 mg a.i./kg bw (135 – 443 mg a.i./kg bw) and a NOEL of 25 mg a.i./kg bw.
- Executive summary:
A study was carried out according to OECD Guideline 401 (Acute Oral Toxicity) and US FIFRA (40 CFR). The study was performed on male and female Sprague Dawley rats at dose levels of 800, 400, 200, 100, 50 and 25 mg a.i./kg bw. All levels were dosed with a 5 % w/w aqueous formulation of DDACarbonate. Rats were observed for 14 days post-dosing. A gross necropsy was performed on any animal that died and at the end of the observation period, all animals were sacrificed for gross necropsy. The acute oral toxicity study revealed a LD50 of 245 mg a.i./kg bw (135 – 443 mg a.i./kg bw) and a NOEL of 25 mg a.i./kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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