Acrylonitrile

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Recent published study

Data source

Reference

Reference Type:

publication

Title:

[Biological monitoring in the molding of plastics and rubbers]

Author:

Fustinoni S., Campo L., Cirla A.M., Cirla P.E., Cutugno V., Lionetti C., Martinotti I., Mossini E., Foal V.

Year:

2007

Bibliographic source:

G. Ital. Med. Lav. Ergon. 29(3 Suppl): 284-6

Materials and methods

Type of study / information:

Biological monitoring data in humans, within the plastics and rubber molding industry

Endpoint addressed:

basic toxicokinetics

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Biological monitoring data in humans

GLP compliance:

no

Remarks:

: not applicable, published monitoring study

Test material

Test material information

Constituent 1

Reference substance name:

Acrylonitrile

EC Number:

203-466-5

EC Name:

Acrylonitrile

Cas Number:

107-13-1

Molecular formula:

C3H3N

IUPAC Name:

prop-2-enenitrile

Method

Ethical approval:

other: informed confirmed consent forms were signed by subjects, no data relating to ethical approval is provided

Details on study design:

Environmental and biological monitoring

Exposure assessment:

not specified

Details on exposure:

Worker exposure in the plastic and rubber molding manufacturing industry

Results and discussion

Results:

Measured airborne concentrations of acrylonitrile were below the measurement limit (10 μg/m3) in all subjects (ABS moulding).

Any other information on results incl. tables

ABS moulding: The results showed very low concentrations of acrylonitrile. 100% of the results were below the measurement limit (10 µg/m³).

Rubber moulding: The airborne PAHs concentration levels found in the 19 study subjects were low. Urinary napthalene and urinary phenanthrene were found to be present in the highest amounts. The other low-boiling point urinary PAHs, whilst present in most samples, showed levels below 10 ng/l. High-boiling point urinary PAHs were always found in amounts lower than the measurement limit. No differences were observed between smokers and non-smokers.

Applicant's summary and conclusion

Conclusions:

Measured airborne concentrations of acrylonitrile were below the measurement limit (10 μg/m3) in all subjects.

Executive summary:

This study was carried out in the plastic and rubber moulding industry, in the “Professional Cancer Prevention Project” with the objective of developing and implementing protocols for evaluating exposure to carcinogens through the biological monitoring. The carcinogenic substances identified were: 1,3-butadiene, acrylonitrile and styrene in moulding ABS, and polycyclic aromatic hydrocarbons (PAH) in moulding rubber. Only for some of these substances biological indicators are available. The limited exposure to airborne chemicals in moulding ABS and the intrinsic characteristics of biological indicators available for 1-3 butadiene have determined the non-applicability of biological monitoring to this situation. Exposure in the rubber moulding was studied in 19 subjects applying the determination not metabolized PAH in urine. The levels of these indicators were similar to those measured in other groups of subjects without occupational exposure to PAH, confirming a low airborne contamination in this workplace.