Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-175-0 | CAS number: 1309-64-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2002-10-28 to 2003-01-27
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: validity criteria not fulfilled, confounding effect of pH decrease on Sb toxicity
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- GLP compliance:
- no
Test material
- Reference substance name:
- Antimony trichloride
- EC Number:
- 233-047-2
- EC Name:
- Antimony trichloride
- Cas Number:
- 10025-91-9
- Molecular formula:
- SbCl3
- IUPAC Name:
- antimony(3+) trichloride
- Test material form:
- not specified
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test substrate
- Details on preparation and application of test substrate:
- - suitable amount of artificial soil was thoroughly mixed with the appropriate amount of SbCl3 dissolved in a small amount of deionized water
- final water content: 50% of maximum water holding capacity
- equilibrated for 1 week under conditions of temperature and light used during the test
Test organisms
- Test organisms (species):
- Enchytraeus albidus
- Animal group:
- annelids
- Details on test organisms:
- - Source: test organisms originate from culture held at Laboratory for Environmental Toxicology since 1995
- Age at test initiation (mean and range, SD): adults with a fully developed clitellum are used for the tests
Study design
- Study type:
- laboratory study
- Substrate type:
- artificial soil
- Total exposure duration:
- 42 d
Test conditions
- Test temperature:
- 20 +/- 1 °C
- pH:
- 6.5 - 3.2 (decreasing pH with increasing SbCl3 dose)
- Moisture:
- soil kept at 50% of max water holding capacity
- Details on test conditions:
- TEST SYSTEM
- Test container (material, size):100 ml glass vessels
- Amount of soil or substrate: 20 g
- No. of organisms per container (treatment): 10
- No. of replicates per treatment group: 4
- No. of replicates per control: 4
SOURCE AND PROPERTIES OF SUBSTRATE (if soil)
- Composition (if artificial substrate): 10% sphagnum peat, 20% kaolin clay, 70ù sand (<200µm), CaCO3 added to adjust pH to 6.0 +/- 0.5
OTHER TEST CONDITIONS
- Photoperiod: 16h:8h light:dark
- Light intensity: 400-800 lux
- feeding: rolled oats, once a week on top of the soil
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- after 21 days, adult enchytraeids are removed and counted. an organism is considered dead if no movement or reaction is observed to a mechanical stimulus
- after 42 days, the soils are submersed with ethanol and Bengal red solution is added in order to facilitate counting of the juveniles. After coloration, the soil is sieved and juveniles are counted.
TEST CONCENTRATIONS
- Spacing factor for test concentrations: factor 3
- Range finding study
- Test concentrations: 1, 10, 100, 1000 and 10000 mg Sb/kg
- Results used to determine the conditions for the definitive study: acute 14d LC50 situated between 1000 and 10000 mg Sb/kg (nominal values). nominal acute 14d NOEC was 1000 mg Sb/kg (measured value: 634 mg Sb/kg dw) - Nominal and measured concentrations:
- nominal: control, 100, 320, 1000, 3200 and 10000 mg Sb/kg dw
measured: 0.37, 59.1, 223, 760, 2012 and 6980 mg Sb/kg dw
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 760 mg/kg soil dw
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- element
- Remarks:
- Sb
- Basis for effect:
- mortality
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 2 012 mg/kg soil dw
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- element
- Remarks:
- Sb
- Basis for effect:
- mortality
- Remarks on result:
- other: 100% effect
- Duration:
- 42 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 760 mg/kg soil dw
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- element
- Remarks:
- Sb
- Basis for effect:
- mortality
- Duration:
- 42 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 2 012 mg/kg soil dw
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- element
- Remarks:
- Sb
- Basis for effect:
- mortality
- Remarks on result:
- other: 100% effect
- Duration:
- 42 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 760 mg/kg soil dw
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- element
- Remarks:
- Sb
- Basis for effect:
- reproduction
- Duration:
- 42 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 2 012 mg/kg soil dw
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- element
- Remarks:
- Sb
- Basis for effect:
- reproduction
- Remarks on result:
- other: 100% effect
- Details on results:
- - average mortality in control soil after 42 days: 5%
- average reproduction in control soil after 42 days: 298 juveniles/replicate (coëfficient of variation = 81 %) - Reported statistics and error estimates:
- EC50s will be determined for the different organisms and endpoints, using appropriate logistic dose-response models. Data for percentage survival are arcsine square root transformed and then tested for normality and homoscedasticity using the Kolmogorov-Smirnov and Bartlett tests. If arcsine square root transformed data do not fulfill the assumptions of a normal distribution, non- parametric statistics (e.g. Kruskal-Wallis) should be used. Significant differences (p< 0.05) of mean survival, growth and reproduction are made using a one-way analysis of variance (ANOVA: Tukey HSD (honest significant difference) test or the Tukey HSD for unequal Nl). Non significant results are regarded as not toxic.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- no
- Executive summary:
The microdrile oligochaete Enchytraeus albidus was exposed to various concentrations of trivalent antimony (SbCl3) in an artificial soil and the endpoints mortality and reproduction were studied. The standard soil used is described and recommended by OECD (1984). This study was performed with 5 replicates per concentration, five concentrations (measured conc. range: 59.1 – 6980 mg Sb/kg dw) and a control (measured conc. 0.37 mg Sb/kg dw), with each replicate consisting of 10 enchytraeids with fully developed clitellum. Four replicates were used for the toxicity test and the remaining replicate was used for the chemical analyses. Adult enchytraeids were exposed for 21 days (which is the period in which cocoons are produced). After this period, the adult enchytraeids were removed from the soil and the survival was examined. The cocoons were incubated for another 21 days (i.e. a total of 42 days) after which reproduction was measured (number of young enchytraeids). The resulting NOEC and LOEC were 760 mg Sb/mg kg dw. and 2012 mg Sb/mg kg dw., respectively, for both endpoints. One of the three performance criteria specified in the OECD test guideline 220 (Enchytraeid reproduction test) that should be met in the control in order for the test to be valid is not fulfilled. This since the coefficient of variation around the mean number of juveniles that should not be higher than 50% at the end of the reproduction phase was 81%. The results from this study are therefore considered not reliable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.