Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-786-5 | CAS number: 110-63-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 433 draft (Acute Inhalation Toxicity: Fixed Concentration Procedure) (not officially approved)
- GLP compliance:
- not specified
- Test type:
- fixed concentration procedure
Test material
- Reference substance name:
- Butane-1,4-diol
- EC Number:
- 203-786-5
- EC Name:
- Butane-1,4-diol
- Cas Number:
- 110-63-4
- Molecular formula:
- C4H10O2
- IUPAC Name:
- butane-1,4-diol
- Details on test material:
- - Analytical purity: 99.7%
- Impurities (identity and concentrations): Water, 2-methyl-1,5-pentanediol, 1,6 hexanediol, tetrahydrofural butanediol acetal, and undefined low and high boilers
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Rats were 7-8 weeks old and weighing between 233 and 271 grams. Male albino Crl:CD@ rats were housed in pairs in 8" x 8" x 14" stainless steel wire mesh cages. Purina Certified Rodent Chow@ 15002 and water were available ad libitum. Rats were weighed and observed for general suitabilityfor at least 1 week prior to test. Animals were restrained in stainless steel holders.
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- not specified
- Details on inhalation exposure:
- Rats were exposed nose-only to atmospheres containing refined 1,4-butanediol for single, 4h periods.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- At 30-minute intervals, calibrated volumeS of test atmosphere were drawn through pre-weighed glass fiber filters. Filters were weighed both wet and dry on a Cahn 26 Automatic Electrobelance@ . Atmospheric concentrations were determined from dry weight ga
- Duration of exposure:
- 4 h
- Concentrations:
- 4.6 mg/L, 9.4 mg/L and 15 mg/L
- No. of animals per sex per dose:
- Summary reports 6 male rats whereas experimental detail reports 10.
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing:daily
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: yes - Statistics:
- LC 50 Calculated by the method of Finney, D. J., Probit Analysis, 3rd Edition, Cambidge University Press (1971)
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 15 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: Mortality 1/10, 1 day post exposure
- Key result
- Sex:
- male
- Dose descriptor:
- discriminating conc.
- Effect level:
- 9.4 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: Mortality 0/10
- Sex:
- male
- Dose descriptor:
- other: No Observed Adverse Effects
- Effect level:
- 4.6 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: Mortality 0/10
- Mortality:
- at 15mg/L 1/10 1day post exposure
- Clinical signs:
- other: During Exposure: Clinical observations could not be made due to the density of chamber atmospheres. When removed from restrainers, all rats exposed to 9.4 and 15 mg/L exhibited lethargic or no movement and labored breathing. At 15 mg/L, rats exhibited red
- Body weight:
- In a dose dependent manner, all rats exhibited slight to severe weight loss 1 day post exposure, followed by the resumption of a normal rate of weight gain.
- Gross pathology:
- no data
Any other information on results incl. tables
An inhalation LC50 of refined 1,4-butanediol could not be calculated from these data as there was only 1/10 mortality at highest dose tested. Higher atmospheric concentrations could not be generated.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.