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Diss Factsheets
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EC number: 219-785-8 | CAS number: 2530-85-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 1975
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: unknown
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 3-trimethoxysilylpropyl methacrylate
- EC Number:
- 219-785-8
- EC Name:
- 3-trimethoxysilylpropyl methacrylate
- Cas Number:
- 2530-85-0
- Molecular formula:
- C10H20O5Si
- IUPAC Name:
- 3-trimethoxysilylpropyl methacrylate
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Sex:
- male
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- water
- Details on exposure:
- The dose was gently massaged, using a glass test tube as the applicator, into the clipped skin on the belly. As the daily dose of 3-(trimethoxysilyl)propyl methacrylate was so large that it couldn't be applied in one inunction, one-fourth of the dose was applied for one minute of each 15 minute-interval during a one-hour period. One hour after the last application, the skin was gently blotted with cleansing tissue to remove any unabsorbed liquid. The animals were weighed before each dose to recalculate dosage application and at study termination.
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 7 applications over 17 days
- Frequency of treatment:
- approximately 2 hours/day on days applied
Doses / concentrations
- Dose / conc.:
- 2 other: ml/kg
- No. of animals per sex per dose:
- 4 males/test material; 4 males/distilled water
- Control animals:
- yes
- Details on study design:
- A group of four male albino rabbits received 7 inunctions, two the first week, three the second week and two the third week at 2.0 ml/kg of 3-(trimethoxysilyl)propyl methacrylate. Based on an LD50 of 20 ml/kg, a maximum dose of 2.0 ml/kg was chosen. A control group was inuncted with 2.0 ml/kg of distilled water.
Examinations
- Observations and examinations performed and frequency:
- All abnormal responses and signs of toxicity, as well as dermal irritation responses were recorded.
- Sacrifice and pathology:
- The study was terminated after 17 days and animals subjected to gross necropsy.
- Other examinations:
- Liver and kidney weights were obtained.
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Dermal irritation:
- effects observed, treatment-related
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Details on results:
- No deaths occurred during the study. There were no differences in body, kidney or liver weights between the treated and control animals. The only abnormal skin response noted on the treated animals was desquamation, which occurred following the third inunction and lasted through study termination. There were no abnormal dermal responses noted in the control group.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 2 other: ml/kg bw
- Sex:
- male
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- In a short-term repeated dose dermal toxicity study, not conducted to any guideline but pre-GLP, the observed effect on the treated animals was desquamation which occurred following the third inunction and lasted through to the study termination. The study is not considered to be reliable.
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