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Diss Factsheets
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EC number: 237-523-0 | CAS number: 13825-74-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Target substance titanium oxide sulphate itself is unstable in water and produces insoluble titanium oxide after rapid hydrolysis. A weight of evidence approach based on studies on titanium dioxide is being proposed. Based on the information available it can be concluded that neither target compound titanium oxide sulphate nor the final hydrolysis transformation products titanium dioxide and sulphuric acid (after neutralisation) exhibit acute toxic effects to aquatic invertebrates.
Key value for chemical safety assessment
Additional information
Titanium oxide sulphate rapidly hydrolyses in water, resulting in the formation of titanium dioxide and causing an increase in acidity. Titanium dioxide is very poorly soluble in water (< 0.1 μg/L); excess titanium dioxide will be present as insoluble matter.
In the study of Bazin (1994), Daphnia were getting exposed to the WAF of the target chemical at a loading rate of 100 mg/l. The EL50 (48h) for titanium oxide sulphate is > 100ppm (weight/weight) (mg/kg). Therefore it is to be concluded that Bazin in fact analysed the effect of titanium dioxide.
For complete assessment of the effects of titanium dioxide on Daphnia, a weight of evidence approach is being suggested, including also the studies on final hydrolysis product titanium dioxide. All studies uniformly show the absence of short-term effects on Daphnia at nominal concentrations that are several orders of magnitude higher than the soluble concentration plus additional load of suspended microdisperse matter in excess. Physical effects on Daphnia might occur as a result of fouling, smothering or coating with high loadings of titanium dioxide precipitate, however such effects are not to be attributed to toxic properties of the substance.
It is concluded that final hydrolysis transformation product titanium dioxide does not exhibit short-term toxic effects to Daphnia at the level of its water solubility in addition with suspended microdisperse matter in excess, even if ingested.
Concerning the target compound titanium oxysulfate itself, the increase of acidity caused by the rapid hydrolysis reaction to form the other final hydrolysis product sulphuric acid is of no relevance for environmental risk assessment under REACH. Within the environmentally relevant pH range sulfuric acid species are being neutralised and thus rendered harmless to biota.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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