Registration Dossier
Registration Dossier
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EC number: 273-733-9 | CAS number: 69012-33-5 By-product of the manufacture of silicomanganese alloy containing oxides of aluminum, calcium, magnesium, manganese and silicon.
Carcinogenicity
Administrative data
Description of key information
A data waiver has been submitted for this endpoint.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
In accordance with criteria for classification as defined in Annex I, Regulation 1272/2008, the substance does not require classification for carcinogenicity.
In accordance with the criteria for classification as defined in Annex VI, Directive 67/548/EEC (DSD) the substance does not require classification for carcinogenicity.
Additional information
According to column 2 (specific rules for adaptation from column 1) point 8.9.1, under Annex X of Regulation 1907/2006, a study may be proposed if:
- the substance has a widespread dispersive use or there is evidence of frequent or long-term human exposure; and
- the substance is classified as mutagen category 3 or there is evidence from the repeated dose study(ies) that the substance is able to induce hyperplasia and/or pre-neoplastic lesions.
As the substance was found to be non-mutagenic from the conclusions of the genetic toxicity tests, and no neoplastic histopathology was noted in the repeated dose studies, and there are no such known reports in humans in the public domain, testing for this endpoint is not proposed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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