Potassium carbonate

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Only short abstract available

Data source

Reference

Reference Type:

publication

Title:

contact hypersensitivity to arsenic in a crystal factory worker

Author:

Barbaud A et all

Year:

1995

Bibliographic source:

Contact Dermatitis 1995: 33, 272

Materials and methods

Type of sensitisation studied:

skin

Study type:

case report

Test guideline

Qualifier:

no guideline available

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Potassium carbonate

EC Number:

209-529-3

EC Name:

Potassium carbonate

Cas Number:

584-08-7

Molecular formula:

CH2O3.2K

IUPAC Name:

dipotassium carbonate

Specific details on test material used for the study:

potassium carbonate 1 % aq. solution

Method

Type of population:

occupational

Ethical approval:

not applicable

Subjects:

A 29- year old man.

Clinical history:

A 29- year old man presented with a 1 -month history of eczema on the hands, arms and legs. The erythematopapular and vesicular lesions predominated in the joint flexures. He worked in a crystal factory, where initially he was a truck driver and had no skin disease. For the last 3 months, he had instead mixed and carried powders used to make crystal: silica, potassium carbonate barium carbonate, sodium carbonate, soda nitrate, red lead, antimony oxide, arsenic (sodium arsenate), and a mixture of erbium, nickel and cobalt. The eczema cleared away from work.

Route of administration:

dermal

Details on study design:

Patch tests were carried out with the European standard series and diluted working products, as follows: silica, as it is; potassium carbonate 1 % aq.; barium carbonate 2 % aq.; sodium carbonate 0.1 % aq.; soda nitrate 1 % aq.; red lead 2 % alc.; antimony oxide, as it is and 2 % aq.; sodium arsenate 1 % aq.; and a mixture of erbium, nickel and cobalt 10 % pet.

Results and discussion

Results of examinations:

No response to potassium carbonate. The only positive test was to sodium arsenate 1 % aq. at 2 and 4 days.

Applicant's summary and conclusion

Conclusions:

No skin sensitisation was observed when potassium carbonate 1 % aqueous solution was applied to the skin of a 29- year old man, with an allergic history, using the patch test method.