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EC number: 203-630-6 | CAS number: 108-93-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Results for a large number of compounds were reported in the publication. Generally acceptable for assessment; restrictions: prior to GLP, limited data documentation.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth Jr HF, Carpenter CP, Weil CS, Pozzani UC & Striegel JA
- Year:
- 1 962
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 23: 95-107
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Remarks:
- Limited documentation of methods and results are provided. It is not clear if a necropsy was performed.
- Principles of method if other than guideline:
- - Principle of test: The test substance is introduced into the stomach of the test animals by gavage. The dosages are arranged in a logarithmic series differing by a factor of 2. Based on the mortalities during a 14day observation period, the most probably LD50 value and its fiducial range are estimated by the method of Thompson using the tables of Weil.
- GLP compliance:
- no
- Remarks:
- Study conducted prior to inception of GLP
- Test type:
- other: Range-finding toxicity test with dosages are arranged in a logarithmic series differing by a factor of 2
- Limit test:
- no
Test material
- Reference substance name:
- Cyclohexanol
- EC Number:
- 203-630-6
- EC Name:
- Cyclohexanol
- Cas Number:
- 108-93-0
- Molecular formula:
- C6H12O
- IUPAC Name:
- cyclohexanol
- Test material form:
- not specified
- Details on test material:
- Supplier: not specified.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Maintained in the colony of the testing facility (appears to be the Mellon Institute of Industrial Research, Pittsburgh, Pennsylvania
- Age at study initiation: 4 to 5 weeks
- Weight at study initiation: 90 to 120 g
- Fasting period before study: No
- Diet: Rockland rat diet, complete
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- VEHICLE
The test material was administered g/kg in a suitable vehicle. Whenever possible, the material was administered undiluted. In the case of lesser concentration, the paper describes a solution in water, corn oil or suspension in semi-solid agar as the preferred expedient. Occasionally, a 1% solution of Tergitol Penetrant 7 (essentially an aqueous solution of 25% sodium 3,9-diethyl-6-tridecanol sulfate) was used as a dispersing agent. The paper did not specify which vehicle was used for the test material. - Doses:
- Not reported. The dosages were arranged in a logarithmic series differing by a factor of 2.
- No. of animals per sex per dose:
- 5 male animals/dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- Based on any mortalities observed during a 14 day observation period, the most probable LD50 value and its fiducial range were estimated by the method of Thompson using the tables of Weil.
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 060 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 950 - 2 180
- Clinical signs:
- other:
- Other findings:
- The single oral LD50 for rats was reported as 2.06 (1.95 - 2.18) g/kg. The figures in parentheses show limits of ± 1.96 standard deviations.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Under the conditions of this study, the single oral LD50 for rats was reported as 2.06 (1.95 - 2.18) g/kg.
- Executive summary:
The acute toxicity of the test material was investigated in a range-finding toxicity test following the principles of the OECD Testing Guideline 401.
Single oral dose toxicity was estimated by the gastric intubation of the substance to groups of five non-fasted, Carworth-Wistar male rats, four to five weeks of age and 90 to 120 grams in weight. The test material was administered g/kg in a suitable vehicle. The dosages were arranged in a logarithmic series differing by a factor of 2. Based on any mortalities observed during a 14 day observation period, the most probable LD50 value and its fiducial range was estimated by the method of Thompson using the tables of Weil. Under the conditions of this study, the single oral LD50 for rats was reported as 2.06 (1.95 - 2.18) g/kg. The figures in parentheses show limits of ± 1.96 standard deviations.
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