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Diss Factsheets
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EC number: 424-450-6 | CAS number: 152628-03-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, B.12 (Mikrokerntest)
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test animals
- Species:
- other: mus, CD-1 (SPF)
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- Suspension der Testsubstanz in Maiskeimöl
"ENGLISH"
Suspension of the test substance in maize germ oil.
- No. of animals per sex per dose:
- Male: 0 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 0 mg/kg; No. of animals: 5; Sacrifice time: 48 hours
Male: 125 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 125 mg/kg; No. of animals: 5; Sacrifice time: 48 hours
Male: 250 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 250 mg/kg; No. of animals: 5; Sacrifice time: 48 hours
Male: 500 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 500 mg/kg; No. of animals: 5; Sacrifice time: 48 hours
Female: 0 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Female: 0 mg/kg; No. of animals: 5; Sacrifice times: 48 hours
Female: 125 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Female: 125 mg/kg; No. of animals: 5; Sacrifice times: 48 hours
Female: 250 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Female: 250 mg/kg; No. of animals: 5; Sacrifice times: 48 hours
Female: 500 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Female: 500 mg/kg; No. of animals: 5; Sacrifice times: 48 hours
Results and discussion
Test results
- Toxicity:
- yes
- Remarks:
- Doses producing toxicity: Bis 500 mg/kg Körpergewicht wurden keine toxischen Effekte beobachtet. "ENGLISH" No toxic effects were observed up to 500 mg/kg body weight.
- Additional information on results:
- Observations:
In den polychromatischen Erythrocyten des Knochenmarks der
mit BIBR 277-BIMS behandelten Tiere wurde keine Zunahme der
Häufigkeit von kleinkernigen polychromatischen Erythrocyten
beobachtet, im Gegensatz zur Positiv-Kontrollgruppe.
Die mit BIBR 277-BIMS behandelten Gruppen zeigten im
Vergleich zu den Vehikel-Kontrollgruppen keine Abnahme des
Verhältnisses von polychromatischen zu normochromatischen
Erythrocyten. Dies deutet auf das Fehlen von toxischen
Effekten dieser Verbindung gegenüber der Erythrocytenbildung
hin. Bei der Positiv-Kontrollgruppe wurde eine Abnahme im
Verhältnis der polychromatischen zu den normochromatischen
Erythrocyten beobachtet.
"ENGLISH"
In contrast to the positive control group, no increase in
the frequency of polychromatic erythrocytes with small
nuclei was observed in the polychromatic erythrocytes of the
bone marrow of the animals treated with BIBR 277-BIMS. In
comparison with the vehicle control groups, the groups
treated with BIBR 277-BIMS did not reveal any decrease in
the ratio of polychromatic to normochromatic erythrocytes.
This is an indication that the compound lacks toxic effects
on the formation of erythrocytes. In the case of the
positive control group, a decrease in the ratio of the
polychromatic to the normochromatic erythrocytes was
observed.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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