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Diss Factsheets
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EC number: 246-910-3 | CAS number: 25376-45-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
No guideline-compliant generation studies are available for 2,4-TDA or the mixture 2,4/2,6-TDA.
2,4-TDA was investigated for effects on male fertility in a series of several feeding studies in Sprague- Dawley rats (Thysen et al. 1984; Thysen 1985 a, b; Varma et al. 1988). The studies revealed that the repeated oral intake of 2,4-TDA dose-dependently affects male fertility and spermatogenesis in rats. Dietary dose-levels of approximately 15 mg/kg bw/d over a 10 week period significantly reduced mating and fertility indices and produced obvious toxic effects on spermatogenesis (66% reduction) associated with a significant reduction in the weights of seminal vesicles and epididymides, morphological damage of Sertoli cells as well as with a diminished level of serum testosterone and an elevation of serum LH. Sperm count and testosterone levels remained low even after a recovery period of 11 weeks. Studies in male mice with oral doses of up to 80 mg/kg did not reveal effects on sperm or impairment of fertility.
Effects on developmental toxicity
Additional information
No guideline-compliant developmental toxicity studies are available for 2,4-TDA or the mixture 2,4/2,6-TDA. However, 2,4-TDA was investigated in a screening assay on 60 chemicals tested at one dose level only. Signs of clear-cut maternal toxicity was noted as 17 out of the 50 dams died and a significantly reduced mean body weight change was observed. In the surviving dams significant reduction of number of live litters (5 out of 20) as well as the number of live born per litter was observed. In the remaining offspring birth weight, weight gain, and viability through the first three postpartum days were not significantly different from that of the control group.
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.