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Diss Factsheets
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EC number: 202-496-6 | CAS number: 96-29-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to generally valid procedures and according to GLP guidelines. All parameters described are closely related or comparable to guideline methods.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
- GLP compliance:
- yes
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- The average lipid content of the test fish was 4.9%, the average weight of the fish was 23.2 g, and the average length of the fish was 9.7 cm.
- Route of exposure:
- aqueous
- Test type:
- not specified
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- ca. 42 d
- Test temperature:
- 25 °C
- Nominal and measured concentrations:
- The nominal concentration of MEKO used in this study was 2 mg/L. Gas chromatography measurements at 2, 3, 4 and 6 weeks measured concentrations of 1.96, 1.96, 1.97 and 1.96 ppm (w/v) MEKO, respectively.
- Lipid content:
- ca. 4.9 %
- Time point:
- start of exposure
- Type:
- BCF
- Value:
- >= 0.5 - <= 0.6 dimensionless
- Time of plateau:
- 2 wk
- Remarks on result:
- other: Conc.in environment / dose:2 mg/l
- Type:
- BCF
- Value:
- 2.5 - 5.8 dimensionless
- Remarks on result:
- other: Conc.in environment / dose:0.2 mg/l
- Remarks:
- <2.5 ~ (5.8)
- Conclusions:
- The BCF for methyl ethyl ketoxime (MEKO) was 0.5 - 0.6 in this study using freshwater fish Cyprinus carpio that were exposed to MEKO at a nominal concentration of 2 mg/L for 42 days.
Reference
BCF at equilibrium:
2 weeks: (0.5) (0.5)
3 weeks: (0.5) (0.5)
4 weeks: (0.6) (0.6)
6 weeks: (0.5) (0.5)
Description of key information
The BCF for MEKO was 0.5 to 0.6 in the study with Cyprinus carpio exposed for 42 days to 2 mg/L MEKO and <2.5 to 5.8 exposed to 0.2 mg/L MEKO, indicating low bioaccumulation potential.
Key value for chemical safety assessment
- BCF (aquatic species):
- 5.8 dimensionless
Additional information
A MITI bioaccumulation assay with freshwater fish, Cyprinus carpio (Ministry of Economy, Trade and Industry (METI), Japan, 1982) conducted according to OECD guideline 305 C was available. BCF values of 0.5-0.6 were found when the fish were exposed to a concentration of 2 mg/L and BCF values ranging from <2.5 to 5.8 were found when exposed to a concentration of 0.2 mg/L, indicating no bioaccumulation potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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