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Diss Factsheets
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EC number: 700-422-1 | CAS number: 61320-65-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study, GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Principles of method if other than guideline:
- 2000 mg/kg bw of the substance is administered orally to 3 female rats as it is at one of the defned doses (5, 50, 300 and 2000 mg/kg bw)..in a stepwise test procedure The starting dose level should be that which is most likely to produce mortality. Absence or presence of compound-related mortality of the animale dosed will determine the next step; i.e. no further testing or dosing of three additional amimals with the same dose or dosing three animals at the mect higher or the nect lower dose level
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- methyl 5-amino-4-cyano-3-methylthiophene-2-carboxylate
- EC Number:
- 700-422-1
- Cas Number:
- 61320-65-8
- Molecular formula:
- C8 H8 N2 O2 S
- IUPAC Name:
- methyl 5-amino-4-cyano-3-methylthiophene-2-carboxylate
- Details on test material:
- content:: 99.1%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 8-12 weeks
- Weight at study initiation: 162-181 g
- Fasting period before study:
- Housing: in groups
- Diet ad libitum
- Water ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22
- Humidity (%): 55
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
-the animal room was provided with sound from a radio program
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Details on oral exposure:
- as a first step female rats received 2000 mg/kg bw in polyethylene glycole and were observd of mortality and clinical signs. as no death occruured in the first trial a second trial was performed with addition 3 female rats using the same dose of the test substance.
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 female rats for each trial
- Control animals:
- no
- Details on study design:
- as described in OECD TG 423
- Statistics:
- During this study for collection, storage and evaluation of data a validated LAN-linked computer system was used, which is desighed and created in-house.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- approximate LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: no mortality occurred
- Mortality:
- The test substance was tolerated without mortalityx
- Clinical signs:
- other: The test substance was toletated without clinical signs
- Gross pathology:
- The test substance was tolertated with out gross pathological findings.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Executive summary:
A study was performed according to OECD TG 423 and GLP to assess the acute oral toxicity to female Wistar rats. A dose of 2000 mg(kg bw in poyethylene glycole was tolerated by female rats without mortalities, clinical signs, effects on weight gain and gross pathological findings. Therefore the test substance is regarded as non-toxic after oral application (Bayer AG 2011).
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