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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient experimental details

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Principles of method if other than guideline:
inhalation of an atmosphere enriched with of the test item at room temperature. For enrichment 200 l air/h are conducted through a 5 cm layer of the test item.
GLP compliance:
no
Remarks:
prior to implementation of GLP
Test type:
other: acute inhalation risk test
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2'-methoxyacetoacetanilide
EC Number:
202-131-0
EC Name:
2'-methoxyacetoacetanilide
Cas Number:
92-15-9
Molecular formula:
C11H13NO3
IUPAC Name:
N-(2-methoxyphenyl)-3-oxobutanamide

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
The test was performed with respect to H.F Smyth et al in Am. Ind. Hyg. Ass. J. (23), 95-107, 1962

Administration / exposure

Route of administration:
other: inhalation: fugative amount of the solid test item
Type of inhalation exposure:
not specified
Vehicle:
air
Details on inhalation exposure:
inhalation of an atmosphere enriched with a fugative amount of the test item at room temperature. For enrichment 200 l air/h are conducted through a 5 cm layer of the test item. Exposure perid: 7h. Observation time at 3, 10, and 30 min, and 1, 3, and 7 h after beginning of treatment.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
ca. 7 h
Concentrations:
no data
No. of animals per sex per dose:
12
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
other: lethality
Effect level:
other: enriched atmosphere, conc. not specified
Based on:
other: fugative amounts of the solid test item
Exp. duration:
7 h
Remarks on result:
other: no lethality
Mortality:
0/12
Clinical signs:
other: no abnormalities
Gross pathology:
no abnormalities
Other findings:
no other findings

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Under the test conditions the test item showed no signs of inhalative toxicity.
Executive summary:

Under the test conditions the test item showed no signs of inhalative toxicity.