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EC number: 241-774-1 | CAS number: 17796-82-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- GLP compliance:
- yes
Test material
- Reference substance name:
- N-(cyclohexylthio)phthalimide
- EC Number:
- 241-774-1
- EC Name:
- N-(cyclohexylthio)phthalimide
- Cas Number:
- 17796-82-6
- Molecular formula:
- C14H15NO2S
- IUPAC Name:
- N-(cyclohexylthio)phthalimide
- Details on test material:
- Batch No.:? 093/06
purity: 99.43% w/w
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Sampling method: mass concentration method, prepared and delivered by Ecotoxicity Group, analysis of samples immediately after delivery
- Sample storage conditions before analysis: at room temperature
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: stirring 2 h + ultrasonic 15 min + filtration
Ca. 30% od Duslin P decomposes during 2 hours.
Test organisms
- Test organisms (species):
- Poecilia reticulata
- Details on test organisms:
- TEST ORGANISM
- Source:Bio Test s.r.o. Konárovice Czech republic
- Age at study initiation (mean and range, SD): 3-4 months old
- Length at study initiation (length definition, mean, range and SD): 2.0 - 3.0 cm
- Weight at study initiation (mean and range, SD): preliminary test - number of fish in beaker: 7, total weight 0.4 -0.7g
full semistatic test- number of fish in beaker: 10 total weight: 1.1-1.3g
- Feeding during test: no food
- without aeration
ACCLIMATION
- Acclimation period: 7 days
- Acclimation conditions (same as test or not): the fish were kept in all-glass aquaria in aerated drinking water
- Type and amount of food: no fed during 72 hours before teh test
- Health during acclimation (any mortality observed): no medical treatment
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- content of sum Ca+Mg ions in dilution water is 2.5 mmol/L
- Test temperature:
- 22+/-2°C with variation of +/- 1°C
- pH:
- dilution water ph=7.8+/-0.2
- Dissolved oxygen:
- preliminary test: stock solution : 8.8 mg/L at 21.2°C
full semi-static test: test solution1: 8.3 mg/L at 21.8°C
2: 8.3 mg/L at 21.2°C
3: 8.7 mg/L at 21.2°C
4: 8.9 mg/L at 21.6°C - Nominal and measured concentrations:
- preliminary test nominal concentration range: 10-1000 mL/L
full semi-static test nominal concentration range : 100-700 mL/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: all-glass aquarium
- Type (delete if not applicable): open / closed
- Material, size, headspace, fill volume:
- Aeration:
- Type of flow-through (e.g. peristaltic or proportional diluter):
- Renewal rate of test solution (frequency/flow rate):
- No. of organisms per vessel: 7 for preliminary test, 10 for semi-static test
- No. of vessels per concentration (replicates):1
- No. of vessels per control (replicates):1
- No. of vessels per vehicle control (replicates):0
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water:prepared just before test by admixing 2.5 mL of stored solution A,B,C and D in 1000mL of distilled water
A= 117.6g CaCl2.2H2O in 1L of distilled water
B= 49.3 g MgSO4.7H2O in 1L of distilled water
C= 25.9 g NaHCO3 in 1L of distilled water
D. 2.3 g KCl in 1L of distilled water
destilled water:
conductivity: 0.165mS/m
pH: 7.6
Oxygen content: 8.8 mg/L at 21.2°C
content of Ca+MG ions is 2.64 mmol/L
- Intervals of water quality measurement: 24 hours
OTHER TEST CONDITIONS
- Photoperiod: daylight
TEST CONCENTRATIONS
- Test concentrations: nominal: 100-700 ml/L - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.69 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- dissolved
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95%CL
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.03 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- dissolved
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95%CL
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.83 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- dissolved
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CL
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.83 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- dissolved
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95%CL
- Duration:
- 24 h
- Dose descriptor:
- LC100
- Effect conc.:
- 1.44 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- dissolved
- Basis for effect:
- mortality (fish)
- Duration:
- 48 h
- Dose descriptor:
- LC100
- Effect conc.:
- 1.15 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- dissolved
- Basis for effect:
- mortality (fish)
- Duration:
- 72 h
- Dose descriptor:
- LC100
- Effect conc.:
- 1.15 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- dissolved
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 1.15 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- dissolved
- Basis for effect:
- mortality (fish)
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.69 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- dissolved
- Basis for effect:
- mortality (fish)
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.39 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- dissolved
- Basis for effect:
- mortality (fish)
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.39 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- dissolved
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.39 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- dissolved
- Basis for effect:
- mortality (fish)
- Results with reference substance (positive control):
- - Results with reference substance valid? YES
- Mortality: meets criteria determined by the interlaboratory test
- LC50: 48h-LC50=143 mg/L
96h- LC50= 137 mg/L
- Other: interlaboratory test 96h-LC50= 96-154 mg/L in 2006
Any other information on results incl. tables
- Sublethal observations / clinical signs:
full semi-static test - Fish mortality
determined conc. TWM mg/L 1.44 0.15 0.69 0.52 0.39 0.31 0.23 C Saturated solution dosing mL/L 700 500 360 260 190 140 100 C Number of live fish 2 h 0 10 10 10 10 10 10 10 mortality % 2 h 100 0 0 0 0 0 0 0 Number of live fish 24 h 0 2 10 10 10 10 10 10 mortality % 24 h 100 80 0 0 0 0 0 0 Number of live fish 48 h 0 0 7 8 10 10 10 10 mortality % 48 h 100 100 30 20 0 0 0 0 Number of live fish 72 h 0 0 7 8 10 10 10 10 mortality % 72 h 100 100 30 20 0 0 0 0 Number of live fish 96 h 0 0 5 8 10 10 10 10 mortality % 96 h 100 100 50 20 0 0 0 0
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- yes for points 1,2,3, not for point 4
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