Registration Dossier
Registration Dossier
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EC number: 200-020-1 | CAS number: 50-23-7
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- Sep to Oct 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well reported GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Hydrocortisone
- EC Number:
- 200-020-1
- EC Name:
- Hydrocortisone
- Cas Number:
- 50-23-7
- Molecular formula:
- C21H30O5
- IUPAC Name:
- 11,17,21-trihydroxypregn-4-ene-3,20-dione
- Details on test material:
- - Name of test material (as cited in study report): hydrocortisone (ZK 5191)
- Analytical purity: 99.3%
- Lot/batch No.: 024H0502
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Duration of test (contact time):
- >= 28 d
Initial test substance concentration
- Initial conc.:
- ca. 20 mg/L
- Based on:
- DOC
Results and discussion
% Degradation
- Parameter:
- % degradation (CO2 evolution)
- Value:
- >= 96
- Sampling time:
- 22 d
- Details on results:
- The degradation of hydrocortisone was rapid after a lag phase of more than 8 days and reached ca. 96% within day 28. 60% degradation was reached approximately by day 19, 6 days after start of degradation (10% degradation).
The reference substance sodium acetate was degraded to 99% on day 5. The biodegradation of the toxic control reached 96%.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The toxicity control did not indicate any inhibiting effect.Thus, hydrocortisone is ready biodegradable.
- Executive summary:
The aerobic biodegradation of hydrocortison was studied in a modified OECD screening test according to test guideline OECD 301E. The test compound was incubated over 28 days at a concentration of 20 mg/L as DOC. Hydrocortioson was degraded to more than 90% at day 28. 60% degradation was reached approximately by day 19, 6 days after start of degradation (10% degradation). The reference compound sodium acetate was degraded to 99% on day 5, the toxicity control did not indicate any inhibiting effect. Thus, hydrocortisone is ready biodegradable.
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