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EC number: 204-116-4 | CAS number: 115-95-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
- Oral: Rat LD50 > 9000 mg/kg bw (BASF AG 1969)
- Dermal: Rabbit: LD50 > 5000 mg/kg bw linalyl acetate (Moreno 1972)
Rabbit: LD50 = 5610 mg/kg bw linalool (Fogleman 1970)
Key value for chemical safety assessment
Additional information
There are valid studies available for the assessment of the acute toxicity of linalyl acetate.
Oral:
In the key study according to internal BASF protocols, ten male and ten female rats were treated with 200, 1600, 3200, 6400, 8000, 10000 µl/kg bw of linalylacetate (BASF AG, 1969). The animals were observed for 7 days, necropsy was performed with dead animals and with the survivors. The LD50 was >10000 µl/kg bw (eq. to > 9000 mg/kg bw) for male and female rats. No mortality was observed at all doses tested. The following clinical signs of toxicity were observed: Immediately following administration hyperactivity, frequent chewing, elevated breathing, piloerection, salivation, dyspnoea, apathia and agitation were seen. On the following days strubby coat, elevated breathing (6400 µl/kg bw) irregular breathing, crouching (8000-10000 µl/kg bw) and slight apathia (10000 µl/kg bw) were seen. In the high dose groups the animals were without findings on day 2, in the 1600 µl/kg bw dosing group the animals were without findings on day 1, in the 200 µl/kg bw group the animals were without any findings. Nothing abnormal was detected at gross pathology.
Further data on acute oral toxicity in rats or mice were only available as short references from secondary sources. These data provided a LD50 range of 12000 to 14550 mg/kg bw (Jenner 1964, RTECS 1994, Bar 1967), substantiating the absence of an acute oral toxicity potential of linalyl acetate.
Inhalation:
In a supportive study, i.e. an standardized inhalation hazard test, 12 rats each were exposed for 8 hours to an atmosphere that had been saturated with the volatile parts of the test compound (vapour) (BASF AG 1969). The test was performed with two different settings concerning the temperature of vapour generation (20°C and 100°C), because at 20°C no significant substance loss was recorded, which means that the enrichment of the air by the volatile parts of the test compound was not detectable. 0/12 rats each died after 8 h exposure at 20°C or at 100°C. At 20°C no symptoms were observed, at 100°C slight mucous membrane irritation and elevated breathing were seen. On day 1 nothing abnormal was detected. At gross necropsy slight bronchitis was seen in animals of the 20°C test. Nothing abnormal was detected there were no necropsy findings in the 100°C test.
No key study is available, however, supportive evidence from an inhalation hazard test does not indicate an acute inhalative toxicity of linalyl acetate, and a study on acute dermal toxicity, covering a relevant route of exposure, is available.
Dermal:
In the key study, being available from secondary sources (a peer-reviewed publication), linalyl acetate was administered to three rabbits, the type of coverage was not further specified (Moreno 1972). Observations were made for mortality and toxic effects for a period of 14 days. The LD50 was reported to be >5000 mg/kg bw.
In support, further evidence for the absence of acute dermal toxicity is provided by an acute dermal toxicity study of the metabolically related substance linalool. Groups of 3 albino rabbits per dose were clipped free of hair from the sides and abdomen. The test material was applied and held in close contact with the skin under Saran wrap and bandages for an exposure period of 24 hours at doses of 2500, 5000, 10000 mg/kg bw (Fogleman 1970). The animals were observed daily and sacrificed on day 7. Gross autopsy was carried out on all animals. At 10000 mg/kg bw 3/3 animals died within the first 24 h of the study. Depression and coma was observed. At 5000 mg/kg bw 1/3 animals died. Depression was observed and remained until the 4thor 5thday. At termination of the study, body weights were unchanged from the initial weights (no weight gain was observed). At 2500 mg/kg bw no effects were seen. The LD50 was set at 5610 mg/kg bw.
Justification for classification or non-classification
The present data on acute oral and dermal toxicity do not fulfill the criteria laid down in 67/548/EEC and 1272/2008/EEC, and therefore, a non-classification is warranted.
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