Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: 215-134-7 | CAS number: 1304-76-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Oral absorption: The assumption appears justified that upon oral uptake the systemic uptake is low for bismuth. An oral absorption factor of 1% will be taken forward for risk characterisation purposes as a conservative assumption.
Inhalation absorption: Considering the very low oral bioavailability and the minimal predicted deposition in the respiratory tract, it is proposed to take forward an inhalation absorption factor of 1% for the purpose of risk characterisation, thus rendering corrections when extrapolating route-to-route (oral-inhalation) unnecessary.
Key value for chemical safety assessment
Additional information
Oral absorption
There are some publications that allow an assessment of the oral bioavailability of bismuth metal in rats, which are however somewhat of age. Information from two review articles(Slikkerveer, A.; de Wolff, F.A. (1989) and Tillman, L.A.; et al. (1996)) that were considered to contain relevant and reliable data are summarised.
For details please refer to the endpoint summary for toxicokinetics, metabolism and distribution.
Inhalation absorption
No data on inhalation absorption and distribution are available for bismuth metal or bismuth compounds.
Nevertheless, after completion of a testing programme on dustiness testing and particle size analysis of the airborne fraction on commercially available forms of bismuth metal powder, dibismuth trioxide and bismuth (III) trinitrate pentahydrate, the collected information can be used to estimate inhalation absorption factors based on a prediction of deposition patterns in the respiratory tract (MPPD model), in accordance with guidance developed under HERAG.
For details please refer to the endpoint summary for toxicokinetics, metabolism and distribution.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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