Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-665-7 | CAS number: 7681-38-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
In view of the acidic reaction to be expected upon dissociation of sodium hydrogensulfite in aqueous media, partial read-across needs to be considered to sulfuric acid, as outlined below. However, the applicability is somewhat restricted since during the gastric passage, an acidic pH (1-2) is already established under normal physiological conditions. Concerning inhalation particle size considerations render solid, commercially available sodium hydrogensulfate as practically unavailable via the inhalation route. Finally, dermal absorption and thus dermal toxicity may be considered negligible. For all other aspects, read-across to sodium sulfate is taken into account in the absence of data specifically for sodium hydrogensulfate.
No data on acute or long-term toxicity of sodium hydrogensulfate are available, thus justified read-across to sodium sulfate and sulfuric acid is performed. Occupational exposure of general population/consumer to sodium hydrogensulfate via inhalation or dermal route is not expected due to the physical and chemical properties (large particle size, low dustiness, inorganic compound).
Sodium sulfate:
Occupational Exposure
Sodium sulphate can exist as dust (by-product) during manufacturing of various chemicals. Occupational exposure to sodium sulphate is possible by dermal contact and inhalation of the dust.
The occupational exposure limit value (OEL) is determined at 10 mg/m3 for an 8 hour exposure
Conclusion and classification:
Sodium sulfate is not toxic to the human. It is a naturally occuring substance which is reduced in the sulfur cycle.
Sodium sulfate does not need to be classsified for human hazards.
Based on read-across from data on sodium sulfate, it is concluded that sodium hydrogensulfate also lacks any toxic potential, and the substance therefore does not require classification for human hazards according to EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 and subsequent regulations.
.General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
In view of the acidic reaction to be expected upon dissociation of sodium hydrogensulfite in aqueous media, partial read-across needs to be considered to sulfuric acid, as outlined below. However, the applicability is somewhat restricted since during the gastric passage, an acidic pH (1-2) is already established under normal physiological conditions. Concerning inhalation particle size considerations render solid, commercially available sodium hydrogensulfate as practically unavailable via the inhalation route. Finally, dermal absorption and thus dermal toxicity may be considered negligible. For all other aspects, read-across to sodium sulfate is taken into account in the absence of data specifically for sodium hydrogensulfate.
No data on acute or long-term toxicity of sodium hydrogensulfate are available, thus justified read-across to sodium sulfate and sulfuric acid is performed. Occupational exposure of general population/consumer to sodium hydrogensulfate via inhalation or dermal route is not expected due to the physical and chemical properties (large particle size, low dustiness, inorganic compound).
Sodium sulfate:
Consumer Exposure
Exposure to sodium sulfate occurs via drinking water and through naturally occurring amounts in foodstuffs. In drinking water (wells) concentrations up to 2 g/l were measured in theUSA. The taste threshold for sodium sulfate is 250 – 900 mg/l. The maximum acceptable concentration for drinking water is 200 – 500 mg/l sulfate, and is based on taste (Ministry of Environment, Lands and Parks Province of British Columbia, Canada, 2000).
No data on the sulfate content of foodstuffs were found; however, according to WHO, sulfates are used as additives in the food industry and the estimated average daily intake of sulfate in food in the USA is 453 mg/person, based on data on food consumption and reported usage of sulfates as additives (WHO, 2003).An Acceptable Daily Intake for sodium sulfate has not been established.
Potential exposure to consumers also occurs from the use of detergents.
WHO/FAO did not set an ADI for sodium sulfate, since they consider this to be a substance of no concern. This was re-confirmed in the joint WHO/FAO meeting of June 2001.
Conclusion and classification:
Sodium sulfate is not toxic to the human. It is a naturally occuring substance which is reduced in the sulfur cycle.
Sodium sulfate does not need to be classsified for human hazards.
Based on read-across from data on sodium sulfate, it is concluded that sodium hydrogensulfate also lacks any toxic potential, and the substance therefore does not require classification for human hazards according to EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008and subsequent regulations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.