Bis(2-dimethylaminoethyl)(methyl)amine

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions (limited documentation, occlusive treatment, no data on substance purity)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Deviations:

yes

Remarks:

(limited documentation, 1, 5, 15 min and 20 h exposure duration, occlusive treatment, no scoring at 72 h)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Bis(2-dimethylaminoethyl)(methyl)amine

EC Number:

221-201-1

EC Name:

Bis(2-dimethylaminoethyl)(methyl)amine

Cas Number:

3030-47-5

Molecular formula:

C9H23N3

IUPAC Name:

(2-{[2-(dimethylamino)ethyl](methyl)amino}ethyl)dimethylamine

Details on test material:

- Name of test substance (as cited in study report): Pentamethyl-diaethylen-trieamin
- Analytical purity: no data
- Physical state: liquid
- Density: 0.829 g/cm³
- Substance number: XXIII/80

Test animals

Species:

rabbit

Strain:

Vienna White

Details on test animals or test system and environmental conditions:

- Source: Gaukler
- Weight at study initiation: 2.94 kg (male), 3.78 kg (female)

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

other: untreated site served as control

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied: area of application: 2.5 x 2.5 cm
- Concentration (if solution): 100%

Duration of treatment / exposure:

1, 5, 15 min and 20 h

Observation period:

8 days (reading intervals: upon removal of test patch, 24 h, 48 h, 5 d, 7 d, and 8 d after start of treatment)

Number of animals:

2 (20 h exposure only in 1 animal)

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

other: necrosis

Basis:

animal #1

Remarks:

(5 min exposure)

Time point:

other: 24 h

Remarks on result:

other: non-reversible, leather-like, black necrosis

Results 2

Irritation parameter:

other: necrosis

Basis:

animal #2

Remarks:

(5 min exposure)

Time point:

other: 24 h

Remarks on result:

other: non-reversible leather-like, red-brown necrosis

Any other information on results incl. tables

Skin irritation:

Exposure duration	Readingpoint	Animal 1			Animal 2
		Ery	Ed	Remarks	Ery	Ed	Remarks
1 min	Day 0	2	0	Blotchy necrosis	2	-	blotchy
	24 h	2	2	Necrosis, ecchymosis	-	-	Blotchy necrosis
	48 h	-	-	Blotchy necrosis	-	-	Blotchy necrosis
	Day 5	-	-	Parchmenty necrosis	-	-	Parchmenty necrosis
	Day 7	-	-	Scaling	-	-	Scaling
	Day 8	-	-	Necrosis	-	-	Scaling
5 min	Day 0	3	-	Ecchymosis	2	-	Brownish
	24 h	2	-	Leather-like, black necrosis	-	-	Leather-like, red-brown necrosis
	48 h	-	-	Leather-like, hard necrosis	-	-	Leather-like, red-brown necrosis
	Day 5	-	-	Hard, movable necrosis	-	-	Leather-like, red-brown necrosis
	Day 7	-	-	Hard, movable necrosis	-	-	Leather-like/hard red-brown necrosis
	Day 8	-	-	Hard, movable necrosis	-	-	Leather-like/hard, red-brown necrosis
15 min	Day 0	3	-	Ecchymosis, yellow	2	-	Brownish, overleaping necrotic centre
	24 h	2	-	Leather-like, black necrosis	-	-	Hard, movable black necrosis
	48 h	-	-	Leather-like, black necrosis	-	-	Hard, movable black necrosis
	Day 5	-	-	Leather-like necrosis	-	-	Hard, movable, black necrosis
	Day 7	-	-	Leather-like necrosis	-	-	Hard, movable black necrosis
	Day 8	-	-	Leather-like necrosis	-	-	Hard, movable black necrosis
20 h	24 h	2	-	Soft, black, anaemic necrosis
	48 h	2	-	Hard movable, black necrosis
	Day 5	-	-	Hard, movable necrosis
	Day 7	-	-	Hard, movable necrosis
	Day 8	-	-	Hard, movable necrosis

Ery: Erythema

Ed: Edema

Applicant's summary and conclusion

Interpretation of results:

Category 1B (corrosive)

Remarks:

Migrated information