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Diss Factsheets
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EC number: 241-004-4 | CAS number: 16940-66-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards with acceptable restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- Development of testicular lesions in F344 rats after treatment with boric acid.
- Author:
- Treinen KA & Chapin RE.
- Year:
- 1 991
- Bibliographic source:
- Toxicology and Applied Pharmacology 107: 325 - 355.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: No data
- Deviations:
- not specified
- Principles of method if other than guideline:
- Six treated (9,000 ppm; equivalent to 348 mg boric acid/kg bw/day, or 61 mg B/kg bw/day) and 4 control animals per time point were killed after 4, 7, 10, 14, 21 and 28 days of exposure.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Boric acid
- IUPAC Name:
- Boric acid
- Details on test material:
- - Name of test material: Boric acid.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 28 days.
- Frequency of treatment:
- Daily; food ad lib.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
9,000 ppm; equivalent to 348 mg boric acid/kg bw/day, or 61 mg B/kg bw/day.
Basis:
nominal in diet
- No. of animals per sex per dose:
- Six males
- Control animals:
- yes, concurrent no treatment
Results and discussion
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- 348 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- other: Based on inhibited spermiation began from day 7 of exposure and increased in severity and number of animals affected afterwards.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Animals were killed after 4, 7, 10, 14, 21 and 28 days of exposure. Inhibited spermiation began from day 7 of exposure and increased in severity and number of animals affected afterwards. At day 10, all exposed animals were affected, with cell death and occluded tubular lumina occurring by day 21. By day 28, there was advanced epithelial disorganisation and a significant loss of spermatocytes and spermatids from tubules at all stages of spermatogenesis. Basal testosterone level in serum was decreased from day 4 and remained lower than controls throughout the observation period. However, stimulated testosterone levels were no different between controls and exposed animals. In their discussion, the authors noted that the earliest effect produced by boric acid in this study was inhibition of spermiation (release of spermatozoa) which appeared by day 7.
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