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EC number: 245-366-4 | CAS number: 22984-54-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 02 Aug - 05 Aug 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- 24 hour occlusive exposure
- GLP compliance:
- yes
Test material
- Reference substance name:
- Butan-2-one O,O',O''-(methylsilylidyne)trioxime
- EC Number:
- 245-366-4
- EC Name:
- Butan-2-one O,O',O''-(methylsilylidyne)trioxime
- Cas Number:
- 22984-54-9
- Molecular formula:
- C13H27N3O3Si
- IUPAC Name:
- butan-2-one O,O',O''-(methylsilanetriyl)oxime
- Test material form:
- liquid: viscous
- Details on test material:
- - Name of test material (as cited in study report): Methyl oximono silane
- Substance type: Alkoxysilane
- Physical state: colorless, viscous liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Pine Acres Rabbitry, W. Brattleboro, VT
- Age at study initiation: 10 - 12 weeks
- Weight at study initiation: 2.2 - 2.6 kg
- Housing: single housing
- Diet: Charles River Rabbit Formula, Lot W1 3151; Agway Rabbit Prolab Formula, Lot W1 3189
- Water: tap water, ad libitum
- Acclimation period: at least 2 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±3
- Humidity (%): 50±15
- Air changes (per hr): 12-16
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: control patches (+ve and -ve) are included on each animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 ml - Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
Reading time points: 1, 24, 48 h (after completion of exposure) - Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm x 2.5 cm
- Type of wrap if used: gauze patch sealed with plastic wrap
REMOVAL OF TEST SUBSTANCE
- Washing: excess test substance was wiped
- Time after start of exposure: 24 h
SCORING SYSTEM: Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Remarks:
- out of all 6 animals
- Time point:
- other: mean over 1, 24, 48 h, after completion of exposure
- Score:
- 0.5
- Max. score:
- 8
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- out of all 6 animals
- Time point:
- 24/48/72 h
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- out of all 6 animals
- Time point:
- 24/48/72 h
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- The test substance caused erythema (Grade 1) to 4 of 6 animals 1 h after removal of the patch. Erythema resolved at 3 sites by 24 h and at the remaining site by 48 h. Edema (Grade 1) was observed at the 4 sites displaying erythema at 1 h after patch removal. The edema had resolved at all 4 sites by 24 h. The Primary Dermal Irritation Index (mean of 1, 24, 48 h, following removal of the patch) was 0.5. The PDII for the negative control (untreated patch) was 0.0, and for the positive control (1% sodium lauryl sulphate) was 6.1.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- CLP Implementation.
- Conclusions:
- A well reported, well conducted but non-standard study, with GLP, identified slight, transient effects to rabbit skin from 24-h occluded contact with the test material. The effects were fully reversible within 48 h, thus the test substance is considered not to be irritant to the skin.
- Executive summary:
A skin irritation study was conducted with a method equivalent to OECD 404 according to GLP standards. Six New Zealand white rabbits were exposed to 0.5 mL test substance (undiluted) for 24 hours under a occlusive coverage. The observation period was 72 hours and reading time points at 1, 24 and 48 hours after completion of exposure. Positive and negative control patches were included on each animal. The reactions were scored according to Draize system. The test substance caused erythema (Grade 1) to 4 of 6 animals 1 h after removal of the patch. Erythema resolved at 3 sites by 24 h and at the remaining site by 48 h. Edema (Grade 1) was observed at the 4 sites displaying erythema at 1 h after patch removal. The edema had resolved at all 4 sites by 24 h. The Primary Dermal Irritation Index (mean of 1, 24, 48 h, following removal of the patch) was 0.5. The PDII for the negative control (untreated patch) was 0.0, and for the positive control (1% sodium lauryl sulphate) was 6.1. The substance was concluded to be non-irritating to the skin.
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