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EC number: 225-625-8 | CAS number: 4979-32-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-1 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- N,N-dicyclohexylbenzothiazole-2-sulphenamide
- EC Number:
- 225-625-8
- EC Name:
- N,N-dicyclohexylbenzothiazole-2-sulphenamide
- Cas Number:
- 4979-32-2
- Molecular formula:
- C19H26N2S2
- IUPAC Name:
- N-(1,3-benzothiazol-2-ylsulfanyl)-N-cyclohexylcyclohexanamine
- Details on test material:
- Santocure DCBS, lot/batch no: 84/129/01, white powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CDr (Sprague-Dawley derivated)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 1 % methocel A15C (Dow)
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 per sex and dose
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: at 24 hours after application some animals exhibited decrease food consumption, several were hypoactive and a few exhibited other abnormalities
- Clinical signs:
- other:
Any other information on results incl. tables
Mortality: all animals survived throughout the study (0/10)
Body weight: 3%5 females exhibited slight weight loss at day 7, but all animals gained weight between days 7 and 14.
Pharmacologic and toxicologic signs: most animals were free of abnormalites on day of dosing. However, at 24 hours animals exhibited decrease food consumption, several were hypoactive and a few exhibited other abnormalities
Abnormalities: nasal discharge (1/10 day 6); red nasal discharge (1/10 day 1); oral discharge (1/10 day 1, 1/10 day 7); wet rales (1/10 2 h); ocular discharge (2/10 at day 1); red ocular discharge (1/10 at day 1, 2 and 3); urinary straining (2/10 day 1); unthrifty coat (1/10 at day 1, 2,4, 5, 6 and 7 and 2/10 at day 3; soft stool (1/10 4 h; hypoactivity: 7/10 day 1, 4/10 day 2, 1/19 day 3;food consumption decreased (10/10 day 1, 6/10 day 2, 3/10 day 3, 1/10 day 4; eyes closed 2/10 day 1 and 2). Abnormalities continued in a few animals through day 7 but all animals were free of abnormalities from day 8 through termination of the study (day 14).
Gross postmortem observation: gross postmortem observations were similar to those seen in control animals in this laboratory.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
In a GLP and guideline study with male and female CDR rats no mortality was observed after treatment with 5000 mg/kg bw. Three of the five treated females exhibited slight weight loss at day 7 but all treated animals gained weight between day 7 and termination of the study (day 14). Most animals were free of abnormalities on the day of dosing. However, after 24 hours all animals exhibited decreased food consumption, several were hypoactive and a few exhibited other abnormalities (nasal discharge, oral discharge, wet rales, ocular discharge, urinary straining, unthrifty coat, soft stool, and eyes closed). In addition, no treatment-related gross pathology findings were noted. Based on these findings, the authors concluded that the LD50 of DCBS in rats is greater than 5000 mg/kg bw (Monsanto 1985).
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