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Long-term toxicity to aquatic invertebrates

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Description of key information

Read-across; test item: barium dichloride; Daphnia magna: NOECC = 2900 µg/L Ba2+ and 4.3 mg/L for BaCl2 (non-guideline study, Biesinger & Christensen, 1972). This would mean a NOEC of 4.9 mg/L for Barium titanium trioxide (calculated from its molecular weight).

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
4.9 mg/L

Additional information

In order to assess the long-term toxicity to aquatic invertebrates of the analogous test substance barium dichloride, the test in Daphnia magna was performed according to generally accepted scientific standards and methodology (Biesinger & Christensen, 1972). General test methods of this study are in line with existing guidelines (e.g., OECD 211) with regard to age and number of test organisms, exposure period, test conditions, volume of test beakers, renewal and endpoints (survival and reproduction).

Five animals per concentration were exposed for 21 days in semi-static freshwater which means the test medium weekly renewed. The nominal/measured test concentrations were not reported. Five to 12 concentrations (not specified); a geometric series of concentrations was used for obtaining an approximation of toxicity; a linear series of concentrations was used for delineating reproductive impairment levels.

 

The EC16 for reproduction was estimated to be 5800 µg/L based on metal ion. According to ECHA methodology, the EC16 (i.e., effects situated between 10 and 20%) can be used to estimate a NOEC-value; ECx (10% < x < 20%) /2 = NOEC. In this case, a NOEC of 2.9 mg/L for Ba2+ has been derived. This would mean a NOEC of 4.9 mg/L for Barium titanium trioxide (calculated from its molecular weight).

Therefore, the test substance barium titanium trioxide does not show a long-term toxicity to aquatic invertebrates as the NOEC is > 1 mg/L under the conditions chosen.