Registration Dossier
Registration Dossier
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EC number: 212-222-7 | CAS number: 770-35-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In both available studies (Buehler and GMPT) no induction of contact hypersensitivity was observed, none of the 20 animals tested in each study showed a positive reaction. Hence, phenoxypropanol is not considered to be a skin sensitzer.
Migrated from Short description of key information:
Two GLP-studies according to OECD guideline 406 (Buehler and Maximization test) are available for phenoxyproppanol.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Based on the clearly negative results of the two skin sensitization studies phenoxypropanol is not expected to be a respiratory sensitizer.
Migrated from Short description of key information:
No data on respiratory sensitization is available for phenoxypropanol.
Justification for classification or non-classification
No sensitization reaction was observed with phenoxypropanol. In both the Maximization test (0/20) and the Buehler test (0/20) the sensitization rate was 0%. According to EU criteria for classification and labelling requirements for dangerous substances as laid down in Annex VI of the EEC Council Directive 671548lEEC (amended by Directive 83/467/EEC) and according to GHS/CLP, phenoxypropanol is not classified as a sensitiser.
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