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EC number: 222-733-7 | CAS number: 3590-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin Corrosivity: The purpose of this test was to evaluate the corrosivity potential of the test material using the EPISKIN(TM) in vitro Reconstituted Human Epidermis (RHE) Model after treatment periods of 3, 60 and 240 minutes. This method was designed to meet the requirements of the OECD Guideline for the Testing of Chemicals No. 431 “In Vitro Skin Corrosion: Human Skin Model Test” (adopted 13 April 2004).
The test material was considered to be Non-Corrosive to the skin and accredited the EU risk phrase of No label and a UN packing group Non-Corrosive.
Skin irritancy: The purpose of this test was to evaluate the skin irritation potential of the test material using the EPISKINTM reconstituted human epidermis model after a treatment period of 15 minutes followed by a post exposure incubation period of 42 hours.
The test material was considered to be Non-Irritant (NI).
Eye irritancy: The purpose of the study was to assess the ocular irritancy potential of the test material in the rabbit following application onto the cornea of the enucleated eye. The results of the study are believed to be of value in predicting the ocular irritation potential of the test material in man. According to the protocol followed the test material was considered to be a Non-Irritant (NI)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin:
There are two key in vitro studies for this endpoint.
- The first study (Warren, 2010) assesses skin corrosivity designed to meet the requirements of the OECD Guideline for the Testing of Chemicals No. 431 “In Vitro Skin Corrosion: Human Skin Model Test” (adopted 13 April 2004).
A reliability rating of 1 was assigned according to the criteria of Klimisch, 1997 as this was conducted to a guideline study and GLP.
- The second study (Warren, 2010) assesses skin irritancy according to a validated in vitro method following the EPISKINTM reconstituted human epidermis model.
A reliability rating of 1 was assigned according to the criteria of Klimisch, 1997 as this was conducted to a validated in vitro method and GLP.
Eye: One key was available for the assessment of this endpoint (Warren, 2010). The study was performed using an in vitro method using RHC tissues
A reliability score of 2 was assigned to the study according to the criteria outlined in Klimisch, 1997.
Justification for classification or non-classification
Skin corrosivity:
The test material was considered to be Non-Corrosive to the skin and accredited the EU risk phrase of No label and a UN packing group Non-Corrosive.
Skin irritancy:
Classification of irritation potential is based upon relative tissue viability following the 15 Minute exposure period followed by the 42 Hour post-exposure incubation period according to the following table:
Criteria forin vitrointerpretation |
Classification |
Mean tissue viability is ≤50% |
Irritant (I) R38 |
Mean tissue viability is >50% |
Non-Irritant (NI) |
The relative mean viability of the test material treated tissues was 100.8% after the 15 Minute exposure period.
The in vitro data indicates that the substance is considered a Non-Irritatant to the skin and so it will therefore not be classified for this endpoint.
Eye:
According to the protocol followed the test material was considered to be a Non-Irritant (NI).
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