Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-676-4 | CAS number: 1341-49-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- other: review
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published peer reviewed paper
Data source
Reference
- Reference Type:
- publication
- Title:
- Risk assessment: ammonium bifluoride in industrial cleaning applications.
- Author:
- Daggett, D.A., Leikin, J.B., Bradshaw, B.D., Carrao, A.M., Heitfeld, F.A., Long, K.E., Ren, S., Hamilton, J.D.
- Year:
- 2 006
- Bibliographic source:
- Toxicological Sciences, 90(1-S): 332-333
Materials and methods
- Type of study / information:
- Risk assessment on the use of ammonium bifluoride in industrial cleaning applications
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Risk assessment on the use of ammonium bifluoride in industrial cleaning applications
- GLP compliance:
- not specified
- Remarks:
- : not relevant
Test material
- Reference substance name:
- Ammonium hydrogendifluoride
- EC Number:
- 215-676-4
- EC Name:
- Ammonium hydrogendifluoride
- Cas Number:
- 1341-49-7
- Molecular formula:
- F2H5N
- IUPAC Name:
- ammonium fluoride hydrofluoride
- Details on test material:
- Ammonium bifluoride is a water soluble white crystal with the chemical formula F2H5N.
Constituent 1
Method
- Ethical approval:
- not applicable
- Details on study design:
- A risk assessment was performed to characterise the risks associated with intended use of ammonium bifluoride as an industrial cleaning agent.
- Exposure assessment:
- estimated
- Details on exposure:
- Chemical uses of ammonium bifluoride include metal cleaning agents, stain removers, etching agents, sterilants, electroplating agents, and in ceramic and glass industries. There have been cases of accidental ingestion of products containing ammonium bifluoride leading to a range of toxic effects including death. The assessment examines chronic fluoride exposure resulting from occupational use of an industrial cleaning product containing ammonium bifluoride. The chronic fluoride exposure model considered incidental ingestion, inhalation, and dermal exposure, with the aggregate absorbed dose being calculated.
Results and discussion
- Results:
- The results of the assessment reportedly indicate that intended use of ammonium bifluoride in industrial cleaning applications is not associated with unreasonable risk for adverse health outcomes.
Any other information on results incl. tables
The results of the assessment reportedly indicate that intended use of ammonium bifluoride in industrial cleaning applications is not associated with unreasonable risk for adverse health outcomes. The results of the risk assessment are not available for review.
Applicant's summary and conclusion
- Conclusions:
- The results of the assessment reportedly indicate that intended use of ammonium bifluoride in industrial cleaning applications is not associated with unreasonable risk for adverse health outcomes.
- Executive summary:
Chemical uses of ammonium bifluoride include metal cleaning agents, stain removers, etching agents, sterilants, electroplating agents, and in ceramic and glass industries. There have been cases of accidental ingestion of products containing ammonium bifluoride leading to a range of toxic effects including death. The assessment examines chronic fluoride exposure resulting from occupational use of an industrial cleaning product containing ammonium bifluoride. The chronic fluoride exposure model considered incidental ingestion, inhalation, and dermal exposure, with the aggregate absorbed dose being calculated. The results of the assessment reportedly indicate that intended use of ammonium bifluoride in industrial cleaning applications is not associated with unreasonable risk for adverse health outcomes. The results of the risk assessment are not available for review
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.