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EC number: 203-911-3 | CAS number: 111-82-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (96 h) > 0.52 mg/L (measured mean concentration) for Oryzias latipes (OECD 203)
LC50 (96 h) > 1000 mg/L (nominal concentration) for Lepomis macrochirus (EPA OPPTS 850.1075)
LC50 (48 h) = 1666 mg/L (nominal concentration) for Leuciscus idus (DIN 38412/15)
Key value for chemical safety assessment
Additional information
Three studies evaluating the acute toxicity of methyl laurate (CAS No. 111-82-0) to fish are available. The key study (Japanese Ministry of the Environment, 2004) was conducted according to OECD Guideline 203 under GLP conditions. Fish (Oryzias latipes) were exposed to the test substance for 120 hours within a flow-through water regime at a nominal concentration of 1 mg/L (nominal, limit test). After the exposure period, no mortality was observed in treatment or control vessels and therefore the 96h (and 120h) LC50 was determined to be > 0.52 mg/L (measured mean concentration). An additional study, performed using a methodology similar to Guideline EPA OPPTS 850.1075 was conducted, at concentrations ranging from 180 to 1000 mg/L. No mortality of Lepomis macrochirusafter 96 hours exposure to the test substance was observed, being the LC50 (96 h) > 1000 mg/L (Calmbacher, 1977). Finally, Richterich and Mühlberg (2001) tested the effect of methyl laurate inLeuciscus idusfor 48 hours (according to German method DIN 38412/15), at nominal concentrations ranging from 1 to 10000 mg/L. Mortality was observed at the highest concentrations tested (3000 and 10000 mg/L), however, since these effects are well over the water solubility of the substance probably are due to physical effects rather than to toxicity.
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