Registration Dossier
Registration Dossier
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EC number: 202-597-5 | CAS number: 97-63-2
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Structure-Toxicity Relationship of Acrylic|Monomers.
- Author:
- Autian J
- Year:
- 1 975
- Bibliographic source:
- Environmental Health Perspectives 11: 141-152 [Review]
- Reference Type:
- publication
- Title:
- Development of a|Toxicity Evaluation Program for Dental Materials and|Products.
- Author:
- Lawrence WH, Malik M, Autian J
- Year:
- 1 974
- Bibliographic source:
- J. Biomed. Mat. Res. 8: 11-34
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethyl methacrylate
- EC Number:
- 202-597-5
- EC Name:
- Ethyl methacrylate
- Cas Number:
- 97-63-2
- Molecular formula:
- C6H10O2
- IUPAC Name:
- ethyl methacrylate
- Details on test material:
- ethyl methacrylate, purity: no data
Commercial source: Rohm & Haas Philadeliphia, Pa.
The substance contained from 5 to 2000 ppm of polymerization inhibitor, monomethyl ether of hydroquinone,
or 100 ppm hydroqunione. The monomer was used as such with no further purification. No more data available.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- The test animals were 25 +/- 5 gm, male albino ICR mice.
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Details on study design:
- Several dose levels of each compound were injected intraperitoneally into groups of ten mice and the mice were observed for 7 days for mortality. Injections were made with a clinical syringe when the dose to be
administered was greater than 1 ml. With a dose of 0.1 to 1.0 ml a tuberculin syringe was used, and for doses of less than 0.1 ml a Hamilton microliter syringe was used. - Statistics:
- Acute LD50-values and 95 % confidence limits were calculated by Cornfield and Mantel's modification of Karber's method.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 247 mg/kg bw
- Remarks on result:
- other: Original value: 1.369 ml/kg equals 10.896 mol/10+6 gm (9.328 - 12.734 mol/10+6 gm) 95 % confidence limit) Density: 0.911 g/cm3
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
