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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Limited documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1955
Report date:
1955

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Company Guideline
Principles of method if other than guideline:
pre-guideline study. According to company guideline.
GLP compliance:
no
Remarks:
previous to GLP implementation

Test material

Constituent 1
Chemical structure
Reference substance name:
4-nitrobenzoic acid
EC Number:
200-526-2
EC Name:
4-nitrobenzoic acid
Cas Number:
62-23-7
Molecular formula:
C7H5NO4
IUPAC Name:
4-nitrobenzoic acid

Test animals

Species:
rat
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Analytical verification of doses or concentrations:
no
Duration of treatment / exposure:
1 g/kg bw/day was administered to 5 rats 7 times within 9 days followed by a two day recovery period.
Doses / concentrations
Remarks:
Doses / Concentrations:
1 g/kg bw/day
Basis:
actual ingested
No. of animals per sex per dose:
5 animals

Examinations

Observations and examinations performed and frequency:
HAEMATOLOGY: Yes, at the beginning and the end of the study
URINALYSIS: Yes, at the beginning and the end of the study
Sacrifice and pathology:
GROSS PATHOLOGY: Yes
HISTOPATHOLOGY: Yes

Results and discussion

Results of examinations

Clinical signs:
not specified
Mortality:
not specified
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
effects observed, treatment-related
Clinical biochemistry findings:
not specified
Urinalysis findings:
no effects observed
Behaviour (functional findings):
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
no effects observed
Histopathological findings: non-neoplastic:
no effects observed
Histopathological findings: neoplastic:
not specified
Details on results:
HAEMATOLOGY: 37 % decrease of erythrocytes and 26 % decrease of hemoglobin, formation of methemoglobin
No macroscopic and microscopic findings at necropsy.

Effect levels

Dose descriptor:
NOAEL
Remarks:
(limit test, effects were observed at the single dose tested)
Effect level:
>= 1 000 mg/kg bw/day (nominal)
Based on:
test mat.
Sex:
not specified
Remarks on result:
not determinable
Remarks:
no NOAEL identified

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion