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EC number: 236-751-8 | CAS number: 13473-90-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Published guideline-comparable studies of the acute oral toxicity of with aluminium nitrate are available in the rat and mouse. No data are presented for acute inhalation toxicity; a waiver is provided for thie endpoint. An acute dermal toxicity study performed with the read-across substance aluminium sulphate is available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published study; detailed findings not reported but data considered adequate for LD50 determination and hazard classification purposes.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- : detailed findings not reported
- Principles of method if other than guideline:
- Guideline-comparable assessment of the oral LD50 in the rat. LD50 results are reported as part of a preliminary investigation into the assesment of efficacy of chelating agents
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Interfauna Iberica (Barcelona, Spain)
- Weight at study initiation: 230-280 g
- Diet: ad libitum, Standard pellet diet (Source: Panlab, Barcelona, Spain)
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
no data - Route of administration:
- oral: gavage
- Vehicle:
- physiological saline
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED:
The concentrations were adjusted so that a 250 g rat received 1 ml. - Doses:
- No data
- No. of animals per sex per dose:
- 3 males and 3 females
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not specified
- Necropsy of survivors performed: not specified
- Other examinations performed: not specified - Statistics:
- The LD50 value was calculated according to the method of Litchfield & Wilcoxon (1949).
- Preliminary study:
- LD50 values were established as part of a preliminary investigation into the assesment of efficacy of chelating agents.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 060
- Based on:
- other: anhydrous salt equivalent
- 95% CL:
- >= 1 760 - <= 2 407
- Remarks on result:
- other: Calculated based on Al3+ content in anhydrous aluminium nitrate
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 263 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 3 103 - <= 4 248
- Remarks on result:
- other: Reported value for the test material: aluminium nitrate nonahydrate
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 261 mg/kg bw
- Based on:
- element
- Remarks:
- : Al
- 95% CL:
- >= 223 - <= 305
- Remarks on result:
- other: Reported value for Al3+ equivalents
- Mortality:
- no data presented
- Clinical signs:
- other: no data presented
- Gross pathology:
- no data presented
- Other findings:
- no data
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 of anhydrous aluminium nitrate in the rat was calculated to be 2060 mg/kg bw.
- Executive summary:
LD50 values for aluminium nitrate were established as part of a preliminary investigation into the assesment of efficacy of chelating agents. The acute oral LD50 of aluminium nitrate nonahydrate in the rat was reported to be 3622 mg/kg bw; equivalent to 261 mg/kg bw Al; equivalent to 2060 mg/kg bw anhydrous aluminium nitrate
Reference
The acute oral LD50 of aluminium nitrate nonahydrate in the rat was reported to be 3622 mg/kg bw; equivalent to 261 mg/kg bw Al; equivalent to 2060 mg/kg bw anhydrous aluminium nitrate
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 060 mg/kg bw
- Quality of whole database:
- Published guideline-comparable studies with aluminium nitrate are available in the rat and mouse
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline-comparable study with some minor deviations
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- :only raw data and limited study information reported. Only 2 males and 2 females tested.
- GLP compliance:
- no
- Remarks:
- : study pre-dates mandatory GLP
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No data
- Duration of exposure:
- 24 hours
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 2 males and 2 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations: daily; weighing: at start and end of the test
- Necropsy of survivors performed: yes - Statistics:
- No data
- Preliminary study:
- Not relevant
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality at 5000 mg/kg bw
- Mortality:
- No mortality occurred following treatment and during the observation period at the 5000 mg/kg dosage level.
- Clinical signs:
- other: Clinical observation data at the 5000 mg/kg dosage: - Males: mild/moderate erythema. Both appear normal 2 days after treatment. - Females: moderate and severe erythema, small areas of haemorrhaging in places where large chunks of compound were pressed int
- Gross pathology:
- Animals in the 5000 mg/kg group showed no gross abnormalities during necropsy, with the exception of 1 male animal which had pale lungs.
- Other findings:
- No data
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 of the read-across substance aluminium sulphate was found to be >:5000 mg/kg bw in the rabbit
- Executive summary:
The read-across substance aluminium sulphate hydrate was evaluated for its acute dermal toxicity potential in New Zealand White rabbits. The study is equivalent to the OECD Guideline 402 (Acute Dermal Toxicity) with deviations. For 24 hours, 5000 mg/kg bw test substance was applied to the skin of 2 male and 2 female rabbits. This application produced some skin irritation such as erythema and haemorrhaging after treatment. No mortality occurred. All rabbits exhibited normal appearance and behaviour on Day 2. The gross necropsy showed no significant gross changes attributable to treatment. The acute dermal LD50 in the rabbit was found to be greater than 5000 mg/kg bw.
Reference
The acute dermal LD50 of the read-across substance aluminium sulphate was found to be >:5000 mg/kg bw in the rabbit
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Guideline-comparable read-across study.
Additional information
Acute oral toxicity
LD50 values for aluminium nitrate were established as part of a preliminary investigation into the assesment of efficacy of chelating agents (Llobet et al, 1987). The acute oral LD50 of aluminium nitrate nonahydrate in the rat was reported to be 3622 mg/kg bw; equivalent to 261 mg/kg bw Al; equivalent to 2060 mg/kg bw anhydrous aluminium nitrate. The acute oral LD50 of aluminium nitrate nonahydrate in the mouse was reported to be 3980 mg/kg bw; equivalent to 286 mg/kg bw Al; equivalent to 2257 mg/kg bw anhydrous aluminium nitrate
Acute inhalation toxicity
A study of acute inhalation toxicity is waived in accordance with Column 2 of Annex VIII of the REACH Regulation, based on the physicochemical properties of the substance. The substance is a non-volatile solid with a large particle size and is most frequently supplied in aqueous solution.
Acute dermal toxicity
A study of acute dermal toxicity is available for the read-across substance aluminium sulphate (Scholler, 1976). No mortality was seen at the limit dose of 5000 mg/kg bw/d. Similarly low acute dermal toxicity can be predicted for aluminium nitrate, based on the results of this study and also taking into account the low acute oral toxicity seen in two species.
Justification for selection of acute toxicity – oral endpoint
Study in the preferred species (rat), reporting the lowest LD50 value
Justification for selection of acute toxicity – dermal endpoint
Only one study available for this endpoint
Justification for classification or non-classification
Available data for acute oral and dermal toxicity do not trigger classification of aluminium nitrate according to the CLP Regulation (Regulation (EU) No. 272/2008) or the Dangerous Substances Directive (67/548/EEC).
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