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EC number: 231-403-1 | CAS number: 7534-94-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Isobornyl methacrylate is of low toxicity by oral route (LD50rat >= 2000 mg/kg).
No fully reliable data are available for the dermal and inhalation
routes.
Due to the low vapour pressure of isobornyl methacrylate, inhalation is
not considered as a relevant pathway of exposure.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- Standard acute method. Study conducted pre-GLP.
- GLP compliance:
- no
- Remarks:
- study conducted pre-GLP
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 179 - 223 g males and 199 - 230 g females
- Fasting period before study: three to four hours prior dosing
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data - Route of administration:
- oral: unspecified
- Vehicle:
- corn oil
- Remarks:
- 10% v/v suspension in corn oil for the 464 µL/kg dose level. Undiluted for the remaining dose levels.
- Doses:
- 464 (10% v/v) suspension in corn oil, 1000, 2150, 4640, and 10000 µL/kg (undiluted) for both sexes. A female group received an additional dose of 21500 µL/kg.
- No. of animals per sex per dose:
- Total number of animals: 55
5 per sex per dose - Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: for mortality and toxicity immeldiately after dosing; 1, 4, and 24 hours post-dosing; and daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3.16 mL/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 6.81 mL/kg bw
- Based on:
- test mat.
- Mortality:
- please see table 1 (Any other information on results incl. tables)
- Clinical signs:
- other: Depression, hunched appearence, ataxia, excessive urination, and labored respiration.
- Other findings:
- Necropsy findings: Females at 464 and 4640 µL/kg exhibited yellow appearing contents at sacrifice; gastrointestinal inflammation andf/or congerstion of the lung lobes was observed in dead animales at the two highest levels.
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Classification based on the criteria of 286/2011/EU Criteria used for interpretation of results: EU
- Conclusions:
- According to the test result: LD50(14days): 3160 mg/kg bw (male rats) the test substance Isobornyl methacrylate has to be classified as practically
nontoxic in rats in respect of its acute oral toxicity (EU GHS criteria; classification based on the criteria of 286/2011/EC). - Executive summary:
In an acute oral toxicity study according to standard acute method conducted pre-GLP, groups of fasted male and female Sprague-Dawley rats were given a single oral dose of Isobornyl methacrylate at a dose levels of 464 (10% v/v) suspension in corn oil, 1000, 2150, 4640, and 10000 µL/kg (undiluted) for both sexes. A female group received an additional dose of 21500 µL/kg. and observed for 14 days.
Oral LD50Combined = > 2000 mg/kg bw
Isobornyl methacrylate is oral practically non toxic in Spraque-Dawley rats (EU GHS no category) based on this LD50test in males and female rats.
UN GHS: Category 5
NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.
Reference
Table 1: Mortality
test concentration [µL/kg] |
dead male/total dosed | dead feamale/total dosed |
464 | 0/5 | 0/5 |
1000 | 0/5 | 0/5 |
2150 | 1/5 | 0/5 |
4650 | 4/5 | 0/5 |
10000 | 5/5 | 5/5 |
21500 | not tested | 5/5 |
Further observations:
Males: Evidence of excessive urination and body weight loss in one animal at the 464 and 1000 µL/kg level, respectively; death in one animal by 24 hours at the 2150 µL/kg level; slight depression, depressed righting and placement reflexes and evidence of excessive urination at the 4650 and 10000 µL/kg level; labored respiration ataxia, red-tinged crusts surrounding the eyes and nares, hunched appearance, weight loss and unkempt fur in one or two animals at the 4640 µL/kg level.
Females: Slight depression and unkempt fur at the 464 µL/kg level; evidence of excessive urination in one animal each at the 464 and 2150 µL/kg levels; depression, hunched appearance, unkempt fur, and/or evidence of excessive urination and/or duarrhea at the 4640, 10000 and 21500 µL/kg levels; labored respiration, ataxia, bloody-appeareing stains on the face and ptosis at the 10000 and 21500 µL/kg levels.
Necropsy findings: Females at 464 and 4640 µL/kg exhibited yellow-appearing contents at sacrifice; gastrointestinal inflammation and/or congestion of the lung lobes was observed in dead animals at the two highest levels.
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Oral
The result of the study indicate a very low acute toxic potential of Isobornyl methacrylate for the test species rat after oral application: the valid LD50 value was greater than 2000 mg/kg bw in rats (Rohm and Haas, 1968).
The study was performed before GLP and OECD guidelines were established and therefore only basic data were available. However, the entire data base provided sufficient information to assess the acute oral toxicity.
Additional information
Isobornyl methacrylate is of low toxicity by oral route (LD50rat >= 2000 mg/kg). No fully reliable data are available for the dermal and inhalation routes.
Due to the low vapour pressure of isobornyl methacrylate, inhalation is not considered as a relevant pathway of exposure.
Justification for classification or non-classification
According to the criteria as of directive 1272/2008/EC, no classification is warranted for the acute toxicity.
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