Registration Dossier
Registration Dossier
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EC number: 200-915-7 | CAS number: 75-91-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
TBHP caused skin sensitisation reactions in Guinea pigs. The induction and challenge regime employed corresponded to TBHP treatment at 0.7% and 2.1% (induction) and 21% (challenge). It is therefore concluded that TBHP caused delayed contact sensitisation in Guinea pigs and must be considered to be a skin sensitiser.
Migrated from Short description of key information:
A key study has been identified as having assessed the skin sensitising potential of TBHP in the guinea via the maximisation method. This study has been conducted in accordance with OECD/EU guidelines and was performed under GLP.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
No evaluation of respiratory sensitisation has been performed.
Justification for classification or non-classification
Based on the results of the key study (Guinea pig maximisation test for skin sensitisation), TBHP is classified as:
- Skin Sensitisation Category 1 (may cause an allergic skin reaction) under Regulation 1272/2008 (EU CLP)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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