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Diss Factsheets
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EC number: 200-652-8 | CAS number: 67-43-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral: 1 acute oral study using DTPA acid; 4 acute oral studies using pentasodium DTPA; 2 acute oral studies using pentapotassium DTPA.
Dermal: 1 acute dermal study using pentapotassium DTPA
Inhalation: 1 acute inhalation study using pentasodium DTPA and 1 using a structurally related compound disodium EDTA (EDTA-Na2H2)
Key value for chemical safety assessment
Additional information
The acute oral toxicity of DTPA is low, with LD50 values for the acid and the salt in excess of 2000 mg/kg bw/day. Limited details are available from the studies regarding the potential cause of mortality, however some of the studies did indicate some apparent effects on the kidneys and liver. There is very little difference in the toxicity associated with the pentapotassium, pentasodium salts of DTPA and the acid when one considers the amount of DTPA provided per dose of each substance.
The acute dermal toxicity of DTPA acid and the sodium and potassium salts is very low (LD50 >2000 mg/kg bw). This is consistent with the fact that the dermal penetration of DTPA is very low (<0.1%), as such, dermal dosing of this material will not result in a high enough systemic dose to produce overt toxicity or mortality.
DTPA acid, potassium and sodium salts are not volatile. Therefore the potential for acute exposure to vapours of these substances is remote. In a study performed using pentasodium DTPA, rats exposed for 8 hours to the vapour generated at room temperature did not suffer any adverse effects. Acute inhalation exposure to the solid form of these materials is self limiting due to the particle sizes of the powders (90% >60 micrometers diameter) which will significantly limit the amount inhaled and delivered to the respiratory tract. Also, workers handling the powdered form are required to wear protection (face masks) and this will further limit the possibility for an acute exposure. If such an exposure were to occur it is not expected that it would be more potent than an oral exposure with respect to systemic toxicity.A structurally-related compound EDTA-Na2H2 showed limited inhalation toxicity (i.e. a 6 -h LC30 value of 1000 mg/m3, corresponding to an estimated 4 -h LC50 value between 1000 and 5000 mg/m3).
Justification for classification or non-classification
DTPA-H5 is considered to meet the requirements for classification for acute toxicity as described in the Guidance on the Application of the CLP criteria, Version 4.0 (2013). The proposed classification for DTPA is Acute Tox 4, H332 Harmful if inhaled.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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