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Diss Factsheets
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EC number: 200-300-3 | CAS number: 56-93-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results.
Data source
Reference
- Reference Type:
- other: TSCA 8e submission
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- 60% solution of Benzyltrimethylammonium chloride in water
- IUPAC Name:
- 60% solution of Benzyltrimethylammonium chloride in water
- Details on test material:
- Benzyltrimethyl Ammonium Chloride (60% solution in water). Lot No. 59.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or test system and environmental conditions:
- Albino rabbits were used. No further details provided
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact and abraded skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 ml was applied to the skin
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- animals were observed at 24 and 72 hours
- Number of animals:
- 6
- Details on study design:
- The test procedure was modeled after that of Draize et al.
Prior to the application of the test material, the hair was clipped from the back and flanks of each rabbit. Two test sites located lateral to the midline of the back approximately ten centimeters apart were selected. One of the two sites was abraded by making four epidermal incisions, two perpendicular to the other two, while the other test site remained intact.
The test material was applied to each of the test sites on each rabbit and occluded with gauze patches which were secured with masking tape. The trunk of each animal was then wrapped with impervious plastic sheeting. The wrap held the patches in position and retarded evaporation of the test material during the 24-hour exposure period.
At the end of 24 hours, the plastic wrappings. patches, and all residual test material were removed. The intact and abraded test sites were examined
and scored separately for erythema and edema on a graded scale of 0 to 4. After 72 hours, the sites were again examined and scored.
Reference:
Draize. John H., Woodard. Geoffrey, and Calvery. Herbert 0., Methods for the Study of Irritation and Toxicity of Substances .Applied Topically to
the Skin and Mucous Membranes. J. Pharm. & Exp. Ther. 82:377 (1944).
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 0.7
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: intact skin was fully reversible within 72 hours
- Irritant / corrosive response data:
- Erythema was observed on intact and abraded skin 24 hours after application of test material. No evidence of edema was noted.
- Other effects:
- No additional information available
Any other information on results incl. tables
Table 1 Dermal Effects following Dermal Exposure to Benzyltrimethylammonium chloride
Irritation Scores for Abraded Skin Sites: | Irritation Scores for Intact Skin Sites at: | |||||||
24 hours | 72 hours | 24 hours | 72 hours | |||||
Animal Number | Erythema | Edema | Erythema | Edema | Erythema | Edema | Erythema | Edema |
1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 |
2 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 |
3 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
4 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 |
5 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 |
6 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Mean | 1.0 | 0.0 | 0.7 | 0.0 | 1.0 | 0.0 | 0.0 | 0.0 |
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Slight dermal irritation,erythema, was observed on intact and abraded skin. While total recovery was noted on intact skin within 72 hours, some erythema was still observed after 72 hours on abraded skin. There was no evidence of edema.
- Executive summary:
The dermal irritation potential of the test material was examined. Slight dermal irritation,erythema, was observed on intact and abraded skin. While total recovery was noted on intact skin within 72 hours, some erythema was still observed after 72 hours on abraded skin. There was no evidence of edema.
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