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Diss Factsheets
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EC number: 203-813-0 | CAS number: 110-89-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Pharmacological studies on alicyclic amines, Report 1: Comparison of pharmacological activities of piperidine with those of other amines
- Author:
- Kasé Y, Miyata T, Yuizono T
- Year:
- 1 967
- Bibliographic source:
- Jpn. J. Pharmacol. 17, 475 - 490
Materials and methods
- Principles of method if other than guideline:
- Acute intraperitoneal toxicity
- GLP compliance:
- no
Test material
- Reference substance name:
- Piperidinium chloride
- EC Number:
- 228-033-8
- EC Name:
- Piperidinium chloride
- Cas Number:
- 6091-44-7
- Molecular formula:
- C5H11N.ClH
- IUPAC Name:
- piperidinium chloride
- Details on test material:
- TS-Freetext:
piperidine hydrochloride
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): piperidine hydrochloride
- Analytical purity: no data
Test animals
- Species:
- mouse
- Strain:
- other: dd
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: no data
- Weight at study initiation: 18-22 g
- no further data
ENVIRONMENTAL CONDITIONS
- no further data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 50 - 500 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 24 hours
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs - Statistics:
- LD50 and its fiducial limit (p=0.05) were calculated by the method of Litchfield-Wilcoxon (J. Pharmac. exp. Ther. 96, 99, 1949) from the lethality observed within 24 hours.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 330 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 269 - 450
- Clinical signs:
- At a dose of 50 mg/kg, the test substance did not elicit any change.
With 100 mg/kg, a decrease in spontaneous motilities and a slight depression of responses to external stimuli such as sound and touch were produced.
With 200 mg/kg, cease of spontaneous movement, disappearance of escape response from the stimulation, cyanosis, tachypnoea, piloerection and tremor of the whole body, and ataxia were observed.
With 250 mg/kg and 300 mg/kg, respiratory arrest occurred during convulsive seizures in 1 and 2 out of 6 cases, respectively.
General toxic symptoms of piperidine in mice were sedation (decrease of spontaneous motilities, and depression of escape reaction) with small doses, tremor and convulsion with large doses.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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